ID A0A3Q2XCY4_HAPBU Unreviewed; 798 AA.
AC A0A3Q2XCY4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Toll-like receptor 2 {ECO:0000256|PIRNR:PIRNR037595};
GN Name=TLR2 {ECO:0000313|Ensembl:ENSHBUP00000033215.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000033215.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000033215.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cooperates with LY96 to mediate the innate immune response to
CC bacterial lipoproteins and other microbial cell wall components.
CC Cooperates with TLR1 or TLR6 to mediate the innate immune response to
CC bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6,
CC leading to NF-kappa-B activation, cytokine secretion and the
CC inflammatory response. {ECO:0000256|PIRNR:PIRNR037595}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR STRING; 8153.ENSHBUP00000033215; -.
DR Ensembl; ENSHBUT00000034868.1; ENSHBUP00000033215.1; ENSHBUG00000019995.1.
DR GeneTree; ENSGT00940000156323; -.
DR OMA; RRVMNSR; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF17; TOLL-LIKE RECEPTOR 2; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..798
FT /note="Toll-like receptor 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018752133"
FT TRANSMEM 583..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 633..787
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 798 AA; 90638 MW; A68F2DBBF98F88A6 CRC64;
MKFLVFVLLV SQCSSLTSQQ CHHCEQTSCD CSSQNLREVP AAASKLITEL DLSLNALETI
MKDDFLSYAA LRALFVNNNR IKTIHEDAFH PLTHLEKLDL SSNQLETLSS GWFQNLTSLH
YLNLLGNKYS TLGQGNIFLP LRSLKTLHFG GPFLQSVSKR DFSGLFGLEE LVFEGNHLQV
YKKGSLRQIG PISHVTLSLS GVFHRDLAVV RAILLDVVHP NTTVTFTDTQ FNKSLQMFPL
HVAIERGATG LSFKNVNMSV SACVQLVNIL SGSELTSVAI EDSQFFEDEE EVFLVDINLK
GLEVIFLRNI DIVWFYRVPE LSFMQNMLTV VRRASVINSK VFVIPCQSTI HFTNLEFLDI
SDNTVADRAF MEMMCYGKED VLLNLRTLNI SRNRLFLINS KLFTKLEKLE NLDMSRNSFD
SMPSTCSWPA SLKFLNLSST SLSEVTSCLP QSLQILDLSR NKLTVFNIEL PLLKELYISG
NKLGNLPDGH LYVSLAVLSI QDNNLAKFSS KNLHDYQSLR VLEAAGNPYV CSCDFVGFVT
NDLMNHKTVV GHDLKSYICD SPDAVRGERV SDVKLSVFEC HTALAISLLC LGILVLCVLI
AGLCYKFSVV WYMKMTWAWL KAKRKPKLKK GVLQYDAFVS YSEMDSGWVE AHLIPALEQS
EPPLRLCLHK RDFVPGGWIV DNIMDAIEKS HRTLFVLSQN FVRSEWCKYE LDYTHFRLFD
QNDDAVVLIL LEPIDKNNIP KKFIRLRKVM NSRTYLEWPX XXXXXXLEWP DDEDQIPAFW
QSLRTAIETP EIDDTNNP
//
