ID A0A3Q2XDX0_HAPBU Unreviewed; 1196 AA.
AC A0A3Q2XDX0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Nidogen 1 {ECO:0000313|Ensembl:ENSHBUP00000033585.1};
GN Name=NID1 {ECO:0000313|Ensembl:ENSHBUP00000033585.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000033585.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000033585.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_005946897.1; XM_005946835.2.
DR AlphaFoldDB; A0A3Q2XDX0; -.
DR STRING; 8153.ENSHBUP00000033585; -.
DR Ensembl; ENSHBUT00000027529.1; ENSHBUP00000033585.1; ENSHBUG00000020581.1.
DR GeneID; 102303834; -.
DR CTD; 562690; -.
DR GeneTree; ENSGT00940000156318; -.
DR OMA; PGTGNQF; -.
DR OrthoDB; 25347at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR CDD; cd00053; EGF; 2.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00255; nidG2; 1.
DR CDD; cd00191; TY; 1.
DR Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR003886; NIDO_dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR46513:SF6; NIDOGEN-1; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF12947; EGF_3; 2.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07474; G2F; 1.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR Pfam; PF06119; NIDO; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00682; G2F; 1.
DR SMART; SM00135; LY; 5.
DR SMART; SM00539; NIDO; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF54511; GFP-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51120; LDLRB; 3.
DR PROSITE; PS51220; NIDO; 1.
DR PROSITE; PS50993; NIDOGEN_G2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1196
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018628512"
FT DOMAIN 99..262
FT /note="NIDO"
FT /evidence="ECO:0000259|PROSITE:PS51220"
FT DOMAIN 390..623
FT /note="Nidogen G2 beta-barrel"
FT /evidence="ECO:0000259|PROSITE:PS50993"
FT DOMAIN 622..663
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 664..706
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 711..752
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 753..789
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 796..867
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REPEAT 938..980
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 981..1023
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1024..1068
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 275..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 837..844
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 1196 AA; 131515 MW; 5231327ABD04CFBF CRC64;
MGWKEQGWIA CLSFLGFVVS VKSISRDELF PFGPSARDQL LEPGNDQTYR LDLSKPVLFY
DGTFLSIFIN TNGFVATTEP ESELTYLGKM PPKFGMIAAL QGDLHTSDGV GKVFFREDSS
PDILRRAAEH INRAFPEDDE INPTNAVVVT WVDVTTHGLE SRGDSGIKKR NTFQLVIASL
ETTSYAIVLY PRDGIKFSSM LVGDTNVIMH AGFSKGLVRG FFSSIKGPYY RTTTDDEQSV
RALAEETNSG LRGVWVYEIG TSPFFSNVAP GEVPELPTEA PPQEDVDAYE ESSAARRPLY
PDRPVVAYPP YLQEQTEVHP VQFQPQNPEV VEVDDPIINV DVFSYNLGSC ANNRNKCSKF
GECRDYANGY CCHCISGFYG NGIQCVAEGK PQRVNGKVHG RVFVGRSPSP VEFANIDLHS
YIVANEGRAY VAISDLPETV GPSLEPLVSI SGVIGWAFAL EHPGFKNGFS IIGGEFTRQA
EVTFMPGNEK LNIRQEFKGI DEHDHLIVST NLEGRVAEVP LGSTIKLDPY SEIYQYNNNL
ITSSSTRDYV VTLPDGSRET RRYQWRETIS FNGCYHSETL RDMKPTQMLS VDHIFAIYDP
AQRLIRFALT SKIGDINGGQ PEQNPCLTGR HGCDTNAVCK VGEGATFTCQ CAAGFSGDGR
ACYDNDECRE DPQLCGPNAI CNNQPGTFRC ECEEGYQFGS DQRTCIKVDR PVDHCEAGTH
TCSPHAQCSY AGGSSYVCTC LQGFTGDGRS CQDIDECQQS RCHSDAVCYN TEGSFTCQCR
PGYSGDGFQC LPGRPKTRCE VHRESILGVS GPQGPRPPIG AYIPTCDNNG QYEPMQCHGS
TGHCWCVDQN GQEISGTRTG PGSRPMCIDH NTGLPPVGPR PRPDVDALTP GTHLLFAQSG
RIEHVPLGGY DMKKNDAKPV LHLPEKVIIG VAYDCVEKMV YWTEITSPSI SKANIEGGVP
TSVISSGLES PEGIAIDHLG RTMFWTDSAK DHIEVASLDG SNRRVLINTD LVNPRAIIAD
PSNGNLYWAD WNRKAPKIET SYMDGSNRRV LVRDNLGLPN GLTYDPHSSQ LCWADAGTHK
MECMDPGRGS RSTVLERIQY PFGMTAFGKN IYYTDWQRDA VIAVDRYASR ESDEFQPQKR
TRLYGIATAY AQCPAGQNYC SGNNGGCSHL CLATPNGRSC KCPDNAAQVG CVEREY
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