ID A0A3Q2XFZ3_HAPBU Unreviewed; 295 AA.
AC A0A3Q2XFZ3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Interferon regulatory factor {ECO:0000256|PIRNR:PIRNR038196};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000034355.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000034355.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|PIRNR:PIRNR038196}.
CC -!- SIMILARITY: Belongs to the IRF family. {ECO:0000256|PIRNR:PIRNR038196}.
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DR RefSeq; XP_014189282.1; XM_014333796.1.
DR AlphaFoldDB; A0A3Q2XFZ3; -.
DR Ensembl; ENSHBUT00000029058.1; ENSHBUP00000034355.1; ENSHBUG00000021875.1.
DR GeneID; 102311869; -.
DR CTD; 792160; -.
DR GeneTree; ENSGT00940000156288; -.
DR OMA; ANMPVSR; -.
DR OrthoDB; 3740806at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR CDD; cd00103; IRF; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR019817; Interferon_reg_fac_CS.
DR InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR InterPro; IPR017431; IRF1/IRF2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR PANTHER; PTHR11949:SF3; INTERFERON REGULATORY FACTOR 1; 1.
DR Pfam; PF00605; IRF; 1.
DR PIRSF; PIRSF038196; IFN_RF1/2; 1.
DR PRINTS; PR00267; INTFRNREGFCT.
DR SMART; SM00348; IRF; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00601; IRF_1; 1.
DR PROSITE; PS51507; IRF_2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|PIRNR:PIRNR038196};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR038196};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Nucleus {ECO:0000256|PIRNR:PIRNR038196};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transcription {ECO:0000256|PIRNR:PIRNR038196};
KW Transcription regulation {ECO:0000256|PIRNR:PIRNR038196};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 5..112
FT /note="IRF tryptophan pentad repeat"
FT /evidence="ECO:0000259|PROSITE:PS51507"
FT REGION 108..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 295 AA; 34123 MW; 011D703AEEA1DD40 CRC64;
MPVSRMRMRP WLEKMIESNT VWGLAWIDKE KTMFSIPWKH AARHGWEVDK DACLFKEWAK
HTGKYSEGQV CDPKTWKANF RCAMNSLPDI EEVKDKSINK GHQAMRVFRM LPASQKSKDK
RTKSRESKGR KKNSVVKMEE REDSYSDTQS PIPALVPEST QENRVDSTVQ TEQPDYFFPT
EVPDWSSTVE IGPDSFINRF QVSPDHSSDY DCPEDIIEIC RKLEKETSHW MTTSSLDDRG
FLCNEPCTSP GSQWSESSSV DDVDDTRPQY TTLADIPNST DEFWNSFCQQ IPLLL
//
