ID   A0A3Q2XGE3_HAPBU        Unreviewed;       472 AA.
AC   A0A3Q2XGE3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE            EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000034525.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000034525.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC         EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_005944283.2; XM_005944221.2.
DR   RefSeq; XP_014196191.1; XM_014340705.1.
DR   RefSeq; XP_014196192.1; XM_014340706.1.
DR   AlphaFoldDB; A0A3Q2XGE3; -.
DR   STRING; 8153.ENSHBUP00000034525; -.
DR   Ensembl; ENSHBUT00000035698.1; ENSHBUP00000034525.1; ENSHBUG00000022134.1.
DR   GeneID; 102306993; -.
DR   CTD; 9604; -.
DR   GeneTree; ENSGT00940000154507; -.
DR   OMA; PRSWCQG; -.
DR   OrthoDB; 4338126at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   CDD; cd20341; BRcat_RBR_RNF14; 1.
DR   CDD; cd20354; Rcat_RBR_RNF14; 1.
DR   CDD; cd16628; RING-HC_RBR_RNF14; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   Gene3D; 2.20.25.20; -; 1.
DR   Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR047548; Rcat_RBR_RNF14.
DR   InterPro; IPR031128; RNF14_RING-HC_Zfn.
DR   InterPro; IPR006575; RWD_dom.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR11685:SF237; E3 UBIQUITIN-PROTEIN LIGASE RNF14; 1.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   Pfam; PF01485; IBR; 2.
DR   Pfam; PF05773; RWD; 1.
DR   SMART; SM00647; IBR; 2.
DR   SMART; SM00591; RWD; 1.
DR   SUPFAM; SSF57850; RING/U-box; 3.
DR   SUPFAM; SSF54495; UBC-like; 1.
DR   PROSITE; PS50908; RWD; 1.
DR   PROSITE; PS51873; TRIAD; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          10..129
FT                   /note="RWD"
FT                   /evidence="ECO:0000259|PROSITE:PS50908"
FT   DOMAIN          212..450
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
FT   DOMAIN          216..261
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
SQ   SEQUENCE   472 AA;  53708 MW;  A499AF38DAE0D0E3 CRC64;
     MSEDKEAQED ELLALASIYD EEEFHRAESA QGGEIQLCLE LPPDFKVVVK GENKTEYNVS
     FLPPLVVNFE IPADYPSTSP PLFTLSCKWM TRAQMSSLCR RLDELWEENQ GCVILFTWIQ
     FLKEEALGFL GIQSPLEIIR GGSKAAMVQF GGHPEKAEEK KKELMNSKSE QKISSSSQLD
     PRTVLLMDPR ADLLPQLLDF DEAQRQRVFD SRVFCCGICF VEKLGSNCLC FKECQHVYCK
     ACMTEYFQIQ IRDGNVQCLN CPEPKCTSLA TPSQVKQLVD EELFARYDRL LLQSSLDLMA
     DVVYCPRQSC ATAVMMEPDT TMGICSACQY AFCTLCKLGY HGVSHCKIRA EELRNLRDEY
     LSATASGQKF MEQRYGKRVI QKAVEESFSR DWLSENCKCC PRCGTNIQKV DGCNKMTCTS
     CKQYFCWLCL GVLSKVNPYS HFNNPHSPCY NQLFLGVDPD EDDDAFWSDE ED
//