ID   A0A3Q2XHL1_HAPBU        Unreviewed;       805 AA.
AC   A0A3Q2XHL1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=SEL1L adaptor subunit of ERAD E3 ubiquitin ligase {ECO:0000313|Ensembl:ENSHBUP00000034995.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000034995.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000034995.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sel-1 family.
CC       {ECO:0000256|ARBA:ARBA00038101}.
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DR   RefSeq; XP_005917670.1; XM_005917608.1.
DR   AlphaFoldDB; A0A3Q2XHL1; -.
DR   STRING; 8153.ENSHBUP00000034995; -.
DR   Ensembl; ENSHBUT00000030297.1; ENSHBUP00000034995.1; ENSHBUG00000022971.1.
DR   GeneID; 102303294; -.
DR   CTD; 6400; -.
DR   GeneTree; ENSGT00940000156671; -.
DR   OrthoDB; 1378605at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   CDD; cd00062; FN2; 1.
DR   Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR000562; FN_type2_dom.
DR   InterPro; IPR036943; FN_type2_sf.
DR   InterPro; IPR013806; Kringle-like.
DR   InterPro; IPR006597; Sel1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR11102:SF147; FIBRONECTIN TYPE-II DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR11102; SEL-1-LIKE PROTEIN; 1.
DR   Pfam; PF00040; fn2; 1.
DR   Pfam; PF08238; Sel1; 11.
DR   PRINTS; PR00013; FNTYPEII.
DR   SMART; SM00059; FN2; 1.
DR   SMART; SM00671; SEL1; 10.
DR   SUPFAM; SSF81901; HCP-like; 3.
DR   SUPFAM; SSF57440; Kringle-like; 1.
DR   PROSITE; PS00023; FN2_1; 1.
DR   PROSITE; PS51092; FN2_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00479}; Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..805
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018566438"
FT   DOMAIN          114..162
FT                   /note="Fibronectin type-II"
FT                   /evidence="ECO:0000259|PROSITE:PS51092"
FT   REGION          32..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          762..805
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..57
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..101
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        762..780
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        119..145
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT   DISULFID        133..160
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
SQ   SEQUENCE   805 AA;  90234 MW;  9ED1D6BB7297FA2D CRC64;
     MGYKKCLKTA RRLYFWGILF IVFSKGVTAD EEQHQDEAPE LKSYHDPDSE EEDVRLSPEI
     VAGISMTTDH SHPEEETQPP SEGLEGEEKE DLPDPPPPVE EKPKEVPVVN GGTAHGEPCI
     FPFLFQETEY IECTTDGRGD GRLWCATTYD YDQDKKWGFC ETEEQAQQRL QAEEAEKQYQ
     TVLRMLNSTT RKTQKKELYE KLLKVAEKGH QKAMEKVAYA MLFGDYMNQN ITKAREMFEK
     LAMEGSPKAQ MALGFLYAAG LGVNSSQAKA LVYYTFGALG GNLLAHMILG YRYWGGVGVP
     QSCESALTHY RLVANQVASD VSLTGGSAVQ RIRLLDEVEN PGSTSGMLEE DLIQYYQFLA
     EKGDVQAQVG LGQLHLHGGR GVEQNHQRAY DYFNQAANAG NTHAMAFLGK MYSEGSEFLP
     QNNETALQYF KKASDLGNPV GQSGLGMAYL YGRGVPVNYE LALKYFQKAA EQGWVDGQLQ
     LGTMYYNGIG VKRDYKQALK FFNLASQAGH ILAFYNLAQM HATGTGVMRS CHTAVELFKN
     VCERGRWSER LMTAYGSFKE GDMDAALVQY LLLAEQGYEV AQSNVAFILD QKGARIFSEN
     ETYPRALLHW TRAAAQGYTV ARIKLGDYHF YGYGTDVDYE TAVIHYRLAS EQQHSAQAMF
     NLGYMHEKGL GIKQDIHLAK RFYDMAAEAS PDAQVPVFLA LCKLGLIYAL QYLQDLNLKE
     LISQVDLDQL LGPEWDLYLM TVIALLLGTV IAYRQRQHQI IVPPRPPAPA PPPRPPQEQP
     QGQAEPQAQE ETPEQGPAQE EEEQH
//