ID A0A3Q2ZAX8_KRYMA Unreviewed; 440 AA.
AC A0A3Q2ZAX8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=NOP2/Sun RNA methyltransferase 3 {ECO:0000313|Ensembl:ENSKMAP00000000756.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000000756.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000000756.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR RefSeq; XP_017296317.1; XM_017440828.1.
DR AlphaFoldDB; A0A3Q2ZAX8; -.
DR SMR; A0A3Q2ZAX8; -.
DR STRING; 37003.ENSKMAP00000000756; -.
DR Ensembl; ENSKMAT00000000786.1; ENSKMAP00000000756.1; ENSKMAG00000000628.1.
DR GeneID; 108250782; -.
DR KEGG; kmr:108250782; -.
DR CTD; 63899; -.
DR GeneTree; ENSGT00940000153665; -.
DR OMA; FNRFNYP; -.
DR OrthoDB; 317522at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR Gene3D; 6.20.240.40; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22808; NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22808:SF8; TRNA (CYTOSINE(34)-C(5))-METHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 133..440
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT ACT_SITE 355
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 229..235
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 252
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 283
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 301
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 440 AA; 49333 MW; 3C95B811D936B95D CRC64;
MWRKIWFETK RIRPIPLSFK CHTAPDGALQ QNKQKGSVKD KVRKTIKKQR AFCSAVLNHF
DHQYSEELGD LWPSARAVLL DPQSWQYGVM LNRFSAVTDI TQILLSLGFS SLPPQTDASA
SLCYGASAAS NSKYEEGQDT LLSPHHISKC PPEDFSLQPD TTSQDSLSEF TLSLPHSSLR
CYIHPHPQRF PSQAHRPGWL KQYYLLNAAS LLPVLALQVR DGDKVLDLCS APGGKAIAIM
QSATPALLCC NEPDPHRRDW LSKTLESFLP RSLNSRVIVS AQDGQFFGHS EAGFYDKVLV
DAPCSNDRSW LYSSTRHQGE QRLKDRARLP VLQAQLLRSA LSAVRRGGVV VYSTCTLSMF
ENHAVVETVL NDFPEAELED LWEEIAVPLS KYFTFSPHPA CGQTQPKPSL LPLNSRLGIL
VVPQPGRTWG PMFLSRIRRK
//
