ID   A0A3Q2ZCK2_KRYMA        Unreviewed;       774 AA.
AC   A0A3Q2ZCK2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Transducin-like enhancer protein 4 {ECO:0000313|Ensembl:ENSKMAP00000000305.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000000305.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000000305.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC       {ECO:0000256|ARBA:ARBA00005969}.
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DR   RefSeq; XP_017262648.1; XM_017407159.1.
DR   AlphaFoldDB; A0A3Q2ZCK2; -.
DR   STRING; 37003.ENSKMAP00000000305; -.
DR   Ensembl; ENSKMAT00000000334.1; ENSKMAP00000000305.1; ENSKMAG00000000288.1.
DR   GeneID; 108230720; -.
DR   CTD; 564019; -.
DR   GeneTree; ENSGT01030000234519; -.
DR   OMA; CTDISND; -.
DR   OrthoDB; 1333122at2759; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR005617; Groucho/TLE_N.
DR   InterPro; IPR009146; Groucho_enhance.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR   PANTHER; PTHR10814:SF32; TRANSDUCIN-LIKE ENHANCER PROTEIN 4 ISOFORM X1; 1.
DR   Pfam; PF03920; TLE_N; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR01850; GROUCHOFAMLY.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   DOMAIN          17..129
FT                   /note="Groucho/TLE N-terminal Q-rich"
FT                   /evidence="ECO:0000259|Pfam:PF03920"
FT   REPEAT          574..615
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          616..657
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          173..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          25..52
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        187..211
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..248
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..327
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   774 AA;  82809 MW;  93F8B8E606F4CB39 CRC64;
     MYPQGRHPVP LQPGQSFKFT VLETLDRIKE EFQFLQAQYH SLKLECEKLA SEKTEMQRHY
     IMYYEMSYGL NIEMHKQAEI VKRLSAICAQ IIPFLSQEHQ QQVVQAVERA KQVTMAELNA
     IIGQQLQHLS HHAPGIPLTP HPSGLSLGAG GSGLLALTGA LGVSAHLASK DERNHLDPEH
     LREGAPSRSK SVSSTDSQPT EERQGPSGGY SSLQGGAEAK RRRCDDKESL PPHSYDSDGD
     KSEDNLVVDV SNEEPNSPAG SPPHSPHGNG LDRAPTLRKE LPGSSSTGEA PSTPNPRSPT
     PGKTKDPAQM DKSQSPLSKS GTPSPSHREA LTPGAPGAPG APGAPGPSTS CLRLVSKAAT
     SADPLALRSP MSVPPGSYPA HFGVVSHAGL NGELASPGGF GGALTLSPQI SAAASAYSRS
     PMVAYDSRSH LRAPGLSSSL PGSSGGKPAY SFHVSADGQM QPVPFPPDAL LGPGIPRHAR
     QIHTLSHGEV VCAVTISTST RHVYTGGKGC VKVWDISQPG SKSPMAQLDC LNRDNYIRSC
     KILPDGRTLI VGGEASTLSI WDLATPTPRI KAELTSSAPA CYALAISPDN KVCFSCCSDG
     NIVVWDLHNQ TLVRQFQGHT DGASCIDISN DGTKLWTGGL DNTVRCWDLR EGRQLQQHDF
     TSQIFSLGYC PTGEWLAVGM ESSNVEVLHV SKPDKYQLHL HESCVLSLKF AYCGKWFVST
     GKDNLLNAWR TPYGASIFQS KESSSVLSCD VSPDDKYIVT GSGDKKATVY EVVY
//