ID A0A3Q2ZG17_KRYMA Unreviewed; 830 AA.
AC A0A3Q2ZG17;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Small conductance calcium-activated potassium channel protein 2-like {ECO:0000313|Ensembl:ENSKMAP00000002671.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000002671.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000002671.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_017280579.1; XM_017425090.1.
DR AlphaFoldDB; A0A3Q2ZG17; -.
DR STRING; 37003.ENSKMAP00000002671; -.
DR Ensembl; ENSKMAT00000002724.1; ENSKMAP00000002671.1; ENSKMAG00000002017.1.
DR GeneID; 108241137; -.
DR KEGG; kmr:108241137; -.
DR CTD; 3782; -.
DR GeneTree; ENSGT00950000182904; -.
DR OMA; GGGCKHR; -.
DR OrthoDB; 4200919at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0016286; F:small conductance calcium-activated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR004178; CaM-bd_dom.
DR InterPro; IPR036122; CaM-bd_dom_sf.
DR InterPro; IPR015449; K_chnl_Ca-activ_SK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR10153; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL; 1.
DR PANTHER; PTHR10153:SF40; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 3; 1.
DR Pfam; PF02888; CaMBD; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR Pfam; PF03530; SK_channel; 1.
DR PRINTS; PR01451; SKCHANNEL.
DR SMART; SM01053; CaMBD; 1.
DR SUPFAM; SSF81327; Small-conductance potassium channel; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 339..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 617..693
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000259|SMART:SM01053"
FT REGION 21..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 698..725
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 30..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..96
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 90585 MW; 2591A8F37D5E89F8 CRC64;
MEPPPSLSLA LLGGSEDEDQ RFLLPLGGIS HSSTAGNQPG SNHSNHTGGS TLDRLNGSTP
SPSSATPNLP PASIPKLPLS SSGAQPLPPP IPNALHPTST PLSSCLGSQH SLSGDNSPVY
NALFYSSHSP SMDRERDRER ERERERERGS KHRQASPLVH RRDSNPFTEI AMSSCKYTGG
VMKPLSRLSA SRRNLIESDS SSETKEGAVL AVAGVTAAGG HDRPRDAPPT CSMTQSSSHQ
PPIQSPPEIV ISSKEDSPYP RRGYDITDST SNQMSIYHQN HALVESRRTQ TDRGSRQGGV
GTVGTGARGS TSKALKRKNQ NIGYKLGHRR ALFEKRKRLS DYALIFGMFG IVVMVIETEL
SWGVYSKSSM YSLALKCLIS LSTVILLGLI IAYHAREVQL FVIDNGADDW RIAMTMERVL
LIALELLVSA VHPVPGDFKF QWRARLAFSY APSQAEADLD MVLSVPMFLR LYLIARVMLL
HSKLFTDASS RSIGALNKVH FNTRFVMKTL MTICPGTVLL VFSISLWIIA AWTVRVCERY
HDAQDVTSNF LGAMWLISIT FLSIGYGDMV PHTYCGKGVC LLTGIMGAGC TALVVAVVAR
KLELTKAEKH VHNFMMDTQL TKRIKNAAAN VLRETWLIYK HTKLMKKIDH SRVRKHQRKF
LQAIHQLRSV KMEQRKLSDQ ANTLVDLSKM QSVMYELMSE LNDRSEDLER QMLSLEQRVE
QLTAGFNALP AHLSATLSAQ HAALVHLLRE RDARDGRGGG NVGGAVVPLS SATSLTTAPV
SVSAVQVAAP PTPLAQISAL SLETPLSPPP LSPEGSLEAS PNPNTSTSSC
//
