ID A0A3Q2ZJL8_KRYMA Unreviewed; 518 AA.
AC A0A3Q2ZJL8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Mucolipin-3-like {ECO:0000313|Ensembl:ENSKMAP00000003796.1};
GN Name=MCOLN3 {ECO:0000313|Ensembl:ENSKMAP00000003796.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000003796.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000003796.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3Q2ZJL8; -.
DR STRING; 37003.ENSKMAP00000003796; -.
DR Ensembl; ENSKMAT00000003869.1; ENSKMAP00000003796.1; ENSKMAG00000002903.1.
DR GeneTree; ENSGT00950000183036; -.
DR OMA; WQARRKF; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF23; MUCOLIPIN-3 ISOFORM X1; 1.
DR Pfam; PF21381; MCLN_ECD; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 61..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..266
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 367..504
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 518 AA; 60461 MW; EB89C3569BA387D7 CRC64;
MEESEPLLTV KAEERRLNGG CRWSTHTLDS NTVEDFRRKL KYFFMNPCEK YRARGRKPWK
LMLQIIKIII ITAQLVSFGL SNKMMAMFKE DNLMTFRHLF LEGFKDHRQG NYALYTKTDV
YDHVYYIMDR YTSLQNLTLG NLAYERVNGE YTPLSICQVL YENVTLDPGR DTFDIDPHIK
KDCISIYPVQ PDSTGLATKV NFSLDFNRLL SVNISFSLKT INLQTVRHHE LPDCYAFHVM
IIFDNHAHSG KINVDVDNDV RIYECRDWNM EGSSGKIDFL LLSFDSVVVL ACLASLILCS
RSIIRGIQLQ FEFNIFFHAY YNKIVTWSER MEFVNGWYIF IIISDTMTIT GSMLKIGIQT
KFLTSYDICS ILLGTATMLV WIGVIRYLCF FQKYNILILT LRAAFPNVIR FCCCAAVIYL
GYCFCGWIVL GPYHDKFRTF DKVTECLFSL INGDDMFGTF LRMRDKSYMV WLFSRLYLYT
FISLFIYMVL SLFIALITDT YETIKVSLSN PYTSCIMP
//