ID   A0A3Q2ZK27_KRYMA        Unreviewed;      1073 AA.
AC   A0A3Q2ZK27;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Family with sequence similarity 13 member A {ECO:0000313|Ensembl:ENSKMAP00000004068.1};
GN   Name=FAM13A {ECO:0000313|Ensembl:ENSKMAP00000004068.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000004068.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000004068.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the FAM13 family.
CC       {ECO:0000256|ARBA:ARBA00007549}.
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DR   RefSeq; XP_017262032.1; XM_017406543.1.
DR   AlphaFoldDB; A0A3Q2ZK27; -.
DR   STRING; 37003.ENSKMAP00000004068; -.
DR   Ensembl; ENSKMAT00000004146.1; ENSKMAP00000004068.1; ENSKMAG00000003069.1.
DR   GeneID; 108230388; -.
DR   KEGG; kmr:108230388; -.
DR   CTD; 10144; -.
DR   GeneTree; ENSGT00950000183033; -.
DR   OMA; ETHYCLL; -.
DR   OrthoDB; 1333388at2759; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR039102; FAM13.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR15904; FAM13; 1.
DR   PANTHER; PTHR15904:SF18; PROTEIN FAM13A; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800}.
FT   DOMAIN          45..233
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          257..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          290..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          435..531
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          591..611
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          686..705
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          782..824
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          996..1026
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        315..329
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..370
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        436..453
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..498
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        505..526
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1073 AA;  120358 MW;  514361AEB35C6D9E CRC64;
     MGAGAMAICH STTAVQVRED MKKMVQMPVL RSRAVAAEHT GLFGASLFEL QEQGLLEDGV
     PLVVRRMVEH LCLHALRQEG LFRVNGNVRE VETLKLRLES GDDVDLFSES DPCTVASLLK
     RYLRDLPGGL VDSTVQQELI RHHEECGDDG SWSVLRDLLQ QLPDIHHGLL RYLCHFLTLV
     ERNHEENRMT ALNLATVFGP SVFRVAPGLQ AIKDQNICNK IMAELIQNYS SIFETDAEPE
     GRPTLITVKS EEAHISDADT KKPSCHLHAN TSPPKIKTRQ HLCAPENVEL VNPSCTNTPK
     AKTRQKKVRK RRNDGQTQAV SQPSPSDCTP RARPFSIPIV LPLTPPLGSP SPEVMDTTPQ
     RDTSRSASSH VVHLVVSSSE GLSSSRDEER PISPFYMSNH LSPVRCRPDV VNFLDQTISS
     AVEQHLFDVI PSADQRSETC ELTTCPSSPR VTLTARQRRR HQREQWEEGL SPRNRAASIR
     ADTNKENIPS SGGSSSGGVV EEPSHRADSQ GERSGGHAER TSKPGKSKHN PTLVALADSQ
     AAHTLRECVA EGPAENHMDP LSKRNEISRK AGLGSASQTL RMKIQESPVA CDPAGRIGGG
     GGEVRASEPD CEDVPRLDLT ALTDDGGNWG EPILACPLQR ESMDREEARL SPHAGGRLIR
     QLLEEDSDPM VSPRFYAYGQ SQQYLDDTEV PPSPPNAHSF ITRRRSSSLG SCDDEREELT
     SAQLTKRIHV LKKKIHRFEE KFEEDRKYRP SHGDKAANPE VLRWLNELAR LRKELKERKL
     IKSEEDLPPQ TRQRSNTLPK SFGSQLDKKP PQEKAPKPPV DSTLESILKK LQEKREEVNR
     PEDIKDMTRE QIGAEKVALQ KALLHYESIH GRPVTKNERQ IMKPLYDRYR LVKQILCRAT
     TIPVIGSPSS KRRGPLLQPI IEGETALFFD DIKEEEDGSE DDSDTKTQIN VTVRPELGVF
     SFMDPMDEEV DGFISPVDEL SPSKTSADMG LSNLHSASMQ ELVEQLQETR EEKKRIRKNL
     KEFEDQFFRQ NGRTVQKEDR SPLADEYHEY KHVKAKLRLL EVLISKRDSS KFI
//