ID   A0A3Q2ZKC3_KRYMA        Unreviewed;       782 AA.
AC   A0A3Q2ZKC3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=ATPase copper transporting beta {ECO:0000313|Ensembl:ENSKMAP00000004086.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000004086.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000004086.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q2ZKC3; -.
DR   STRING; 37003.ENSKMAP00000004086; -.
DR   Ensembl; ENSKMAT00000004164.1; ENSKMAP00000004086.1; ENSKMAG00000003095.1.
DR   GeneTree; ENSGT00940000155749; -.
DR   OMA; CTGKVEQ; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0140581; F:P-type monovalent copper transporter activity; IEA:UniProtKB-EC.
DR   CDD; cd00371; HMA; 4.
DR   Gene3D; 3.30.70.100; -; 4.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR017969; Heavy-metal-associated_CS.
DR   InterPro; IPR006122; HMA_Cu_ion-bd.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   NCBIfam; TIGR00003; copper ion binding protein; 3.
DR   PANTHER; PTHR46594; P-TYPE CATION-TRANSPORTING ATPASE; 1.
DR   PANTHER; PTHR46594:SF8; P-TYPE CU(+) TRANSPORTER; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF00403; HMA; 4.
DR   PRINTS; PR00942; CUATPASEI.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF55008; HMA, heavy metal-associated domain; 4.
DR   PROSITE; PS01047; HMA_1; 4.
DR   PROSITE; PS50846; HMA_2; 4.
PE   4: Predicted;
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022796};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022796}.
FT   TRANSMEM        538..556
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        576..594
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        733..755
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          164..230
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          250..316
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          374..440
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          450..516
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   REGION          36..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   782 AA;  84378 MW;  44B4E0788B23C4B6 CRC64;
     HFVEKRAVSL RENDVRASRA SPALISRADH FLDFRPPALP RRREGRSSRH VPLQVSPEPA
     RVRVRVRRNA PDAEQRGFDN LAYEYGSQKE LHPPPKAASR TTFRLPGLTW ERRAVETTLL
     RLGGVLAVSW SGPGALLQVD YDASATAAAD IALQLQSLGC AVEAAAQLKV DGMRCQSCVR
     SIEGRIGGLP GVSRVQVSLQ DGVAVIVHQP LIITQQELKD KIEDMGFDAV LSPEDPSGGD
     QSCWTEDFLK TVTLWIGGMT CGSCVQSVEG RICEVPGVKS VVVSLEEKMG EITFDPSWAE
     PERLRALIQE MGFDASLKGT RSQCLTFFDE SFYLFLLNAC SRLVLETVQR KGLPHAPISN
     GSGSQVTPAE TKVQKCFICV TGMTCASCVA NIERHVLKHK GIRSVLVSLM AGKAEVKYDP
     DVLNAAAVTQ LIQDLGFGAK LMEDDAATHG ELDLLVSGVT CASCVRSIES KLASTKGILS
     ASVALATKKA HIQFDPEVLG ARDIVRVIQS LGFEAGLEKS EFKNNLDHTE EIQQWKNSFL
     LSLVFGLPVM GLMIYMMVMD GQHQDHGGSM PEEQNILPGL SLLNLAFFLL CTPVQRKTSE
     ALAKLVSLQA TDATVVTLGA DHAVVSEEQV VVELVQRGDV VKVAPGGRFP VDGRVIEGSS
     MADESLITGE PMPVSKKVGS LVIAGSINAH GALLVEATHV GPDTTLSQIV KLVEEAQTSK
     APIQQFADRL SGYFVPFIVL VSLLTLGAWL VVGFLDFDVV KENFPVGPIC RTPSQEAAPA
     PP
//