ID A0A3Q2ZLC7_KRYMA Unreviewed; 626 AA.
AC A0A3Q2ZLC7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=SH2 domain-containing protein 3C {ECO:0000313|Ensembl:ENSKMAP00000004426.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000004426.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000004426.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_017283353.1; XM_017427864.1.
DR AlphaFoldDB; A0A3Q2ZLC7; -.
DR Ensembl; ENSKMAT00000004511.1; ENSKMAP00000004426.1; ENSKMAG00000003306.1.
DR GeneTree; ENSGT00940000154130; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR PANTHER; PTHR14247:SF6; SH2 DOMAIN-CONTAINING PROTEIN 3C; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 49..148
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 354..622
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 168..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 626 AA; 69824 MW; 24D1B9D3C7F17B0F CRC64;
MSSEVTSGSG EYVKFCKEKF WLEPPSETLR KELEEELKLS GSNLKSHAWY HGRIPWEVSQ
TLVLNHGDFL IRDSQSSPGN FVLTCSWEQK TLHFLIWKTV VLSGETYTQV RYGLEGEAFD
SLPALVHYYV GSRVVLTQSS GAQIHTPVNR TLPISFLEAT FCTAVSPHPH QRGLKSGGVG
GGGRVRPNSP SCLQHKRTEV PGQPDSPCLM IDGESYISSP DDRTSPTRSP RSSQAASVTP
SPNLSRCSDT TRSMSSLNIS HPHLEQDPPS SEKDGNCYTE LYPQSYVERL QVEKGSSSAD
PLRTEDGNVS FSPVVEAVSC FKPSRYLSAL MPKENKPLEV NILRRVKELL VEVDPRTVAK
HITKTDCVVA RILEVTPEMQ RMMGVSSGTE LLTLPQGQQL RLDLLERFQS MAIVFAVNVL
GCSGTVEERA ALLHKIIQIA AELKTTMGNL FGFAAVMRAL ELPQVSRLEQ TWTVLRQRHT
DGAILYEKTL RPFLKSLNDG RESCPLYNTT FPHVLPLLIL LEKSSAVGER MEPWEMAEVS
VDVVMFHLGA ARTMAQLGGI YRSNAEGKLQ GFQEQDEVRE VFLTDFQMRL LWGSRGAEEN
QGLRFSKFDQ VLTALSNKLE PPLRRT
//
