ID A0A3Q2ZLS2_KRYMA Unreviewed; 300 AA.
AC A0A3Q2ZLS2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Insulin-like growth factor-binding protein 2-A {ECO:0000313|Ensembl:ENSKMAP00000003850.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000003850.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000003850.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR RefSeq; XP_017282409.1; XM_017426920.1.
DR AlphaFoldDB; A0A3Q2ZLS2; -.
DR STRING; 37003.ENSKMAP00000003850; -.
DR Ensembl; ENSKMAT00000003923.1; ENSKMAP00000003850.1; ENSKMAG00000002915.1.
DR GeneID; 108242206; -.
DR KEGG; kmr:108242206; -.
DR CTD; 794176; -.
DR GeneTree; ENSGT00940000158542; -.
DR OrthoDB; 5394492at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031994; F:insulin-like growth factor I binding; IEA:Ensembl.
DR GO; GO:0031995; F:insulin-like growth factor II binding; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0048640; P:negative regulation of developmental growth; IEA:Ensembl.
DR GO; GO:0008156; P:negative regulation of DNA replication; IEA:Ensembl.
DR GO; GO:0043567; P:regulation of insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
DR CDD; cd00191; TY; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR012210; IGFBP-2.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR022321; IGFBP_1-6_chordata.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR PANTHER; PTHR11551:SF5; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PRINTS; PR01976; IGFBPFAMILY.
DR PRINTS; PR01978; IGFBPFAMILY2.
DR SMART; SM00121; IB; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 37..300
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018637553"
FT DOMAIN 42..123
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 201..283
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 119..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 300 AA; 33427 MW; 9E99074DE82551C4 CRC64;
MTRTEVLLPG TMLRFSGCSP PPLLLLLLLL SPPVAGASLA EMVFRCPGCT AERQALCPRL
AETCAEMVRE PGCGCCPACA RQEGEACGVY TPRCSTGLRC YPTPDSELPL EQLVQGQGQC
RRRVEPEAAA SSPEQREQSS GEAVELQPDQ DVSEIPALRR PTKETTWLGP KESAVRQHRQ
EMKTKMKTNK VEEVRPTRPK QTQCQQELDQ VLERISKMPF RDNRGPLEDL YALHIPNCDK
RGQYNLKQCK MSLHGQRGEC WCVDPHTGRR IPSAPTVRGD PNCSQYLTEL ELELADTAQI
//
