ID A0A3Q2ZNM5_KRYMA Unreviewed; 706 AA.
AC A0A3Q2ZNM5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Hedgehog interacting protein {ECO:0000313|Ensembl:ENSKMAP00000005286.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000005286.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000005286.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_017264004.1; XM_017408515.1.
DR AlphaFoldDB; A0A3Q2ZNM5; -.
DR STRING; 37003.ENSKMAP00000005286; -.
DR Ensembl; ENSKMAT00000005378.1; ENSKMAP00000005286.1; ENSKMAG00000003991.1.
DR GeneID; 108231437; -.
DR KEGG; kmr:108231437; -.
DR CTD; 64399; -.
DR GeneTree; ENSGT00940000158660; -.
DR OMA; RMPHREP; -.
DR OrthoDB; 344738at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR012938; Glc/Sorbosone_DH.
DR InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR PANTHER; PTHR19328; HEDGEHOG-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR19328:SF27; HEDGEHOG-INTERACTING PROTEIN; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF07995; GSDH; 1.
DR SMART; SM00181; EGF; 2.
DR SUPFAM; SSF50952; Soluble quinoprotein glucose dehydrogenase; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..706
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018669902"
FT DOMAIN 640..672
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 644..654
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 662..671
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 706 AA; 79124 MW; 0F441218908A5086 CRC64;
MKHLQFVLVL AIAVNMWECG DAKFGERGEL SPRRRRCYDG SLPKRLKRRE RKVLFDSSSS
GGSSSGSSSE VCHTLYPRVS CCPTRRAAYQ ILHRRDARIF STNNTECGLL LEEIKCARCS
PNAQVLFHSL DMDRMPHREP DLPRLCQDFC REFYYTCRGH IPELFQADVD EFCQYYGRRG
SSLCFPDFQR RHLLGQDSNY LEDEKIEDIS RKHKHNCYCA QEVLSGLRQP VAVVHCGDGS
QRIFVLEREG TVKILNHNLE LIKEPFLDLH KLVQKGLKSG DERGLLSLAF HPNYKKNGKL
YVSYTTNQER WAIGPHDHIL RVVEYTVSRK NPNQVDTRTV RVLMEVAELH RKHLGGQLLF
TPDGLLHIIL GDGMITLDDM EEMDGLSDFT GSILRVDVDT DVCTSTYSIP RDNPYFNSTN
QPPEIFAHGL HDPGRCAVDR LQTDNGSLVI LCTDASGKNM SAGRILEITK GKDYENEPSV
YDLQSSGGTP PVGGFIYRGC QSRRLYGNYV FGDKNGNLRI LQKSAFATSS SGEQWQEKAL
CLGSAGSCAS SLVGHILGFG EDELGEVYIL ASSKSMAQSH SGKLYKLVDP KRPHAPKECQ
RQVQPPELLM TACSRYCKNG LCTPTGKCCC SPGWEGPFCR IAKCEPACRN GGVCIEPNKC
LCKSGYSGAQ CEKSEQGMPN DQEKDGILDH IIDMTSYLLD LTSYIV
//
