ID A0A3Q2ZR43_KRYMA Unreviewed; 754 AA.
AC A0A3Q2ZR43;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Rho GTPase activating protein 10 {ECO:0000313|Ensembl:ENSKMAP00000005630.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000005630.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000005630.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_017264602.1; XM_017409113.1.
DR AlphaFoldDB; A0A3Q2ZR43; -.
DR STRING; 37003.ENSKMAP00000005630; -.
DR Ensembl; ENSKMAT00000005729.1; ENSKMAP00000005630.1; ENSKMAG00000004279.1.
DR GeneID; 108231815; -.
DR KEGG; kmr:108231815; -.
DR CTD; 79658; -.
DR GeneTree; ENSGT00940000159559; -.
DR OMA; PIGHYLM; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF5; RHO GTPASE-ACTIVATING PROTEIN 10; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 265..372
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 389..573
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 696..754
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 576..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 754 AA; 85301 MW; 460CC003287C7E28 CRC64;
MGLHPLEFSE CYLDSPSFRE KIKAHEAELD KTNRFIKELY KDGKNLINAT KQLVLAQRKF
ATSLGDFHFE YIGDAKTDDE ICIDKSLQEF SSFLTNLEEQ RELMMKNITE TLMKPLEKFR
KEQLGAIRAE RKKYDKETEK YYSSLEKLLN MSAKKKEPQL QEAAIQVETM RQHFQEESLD
YVCRLQEIQE RKKFDCVEPM VTFFQTVFTF YHHGYELAKD FDHYKRELQI NIQNTRNRFE
GTRSEVFELK KRIREAPQEY RQTSPISFEG YLYVQEKRPP PFGSSWVKRY CTFVKEQKIL
HMVTFDHRSG GKIGETESVT LRSCVRKTTD TLDRRFCLDL DITDRPGTVL TVQAMSEDDH
KLWMQAMGGK EPIGCYLGRT LSKERGIDAQ LDSVGLTFVQ NSINAIETRG INDQGLYRVG
GVSSKVQKLL SLMIDEKSND LDLSASEDWD VKTITSALKL YLRCLPEPLM TYGLYKEFIS
PAKGGSPESR IQAIHCLVHK LPERNRQVLG LLMKHLANVA AHSQQNLMTV ANLGVVFGPT
LMRPQEETVA AIMDLKFQNI VVEILIEQHE KIFTDAPDMS PLSPAGPAFS APTRQSKKQS
RQNRPLAVYN PQVLDIQNAI VDGSNLTADE TSMGSNESVS SQSSSASTSD LADLAASFSI
SSNSRCSLVA ASGASGESQP AAPTAAHEKE KQEQSVTGRK AKAVYPCEAE HDSELSFQVG
AIFSAVTQSR EPGWLEGELE GKRGLIPENY VELL
//
