ID   A0A3Q2ZSB5_KRYMA        Unreviewed;       396 AA.
AC   A0A3Q2ZSB5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Cytoplasmic protein {ECO:0000256|PIRNR:PIRNR037874};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000001099.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000001099.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037874}.
CC       Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR037874}.
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DR   RefSeq; XP_017265563.1; XM_017410074.1.
DR   RefSeq; XP_017265564.1; XM_017410075.1.
DR   AlphaFoldDB; A0A3Q2ZSB5; -.
DR   STRING; 37003.ENSKMAP00000001099; -.
DR   Ensembl; ENSKMAT00000001135.1; ENSKMAP00000001099.1; ENSKMAG00000000872.1.
DR   GeneID; 108232338; -.
DR   KEGG; kmr:108232338; -.
DR   CTD; 393972; -.
DR   GeneTree; ENSGT00940000157728; -.
DR   OMA; TWYYGAI; -.
DR   OrthoDB; 25798at2759; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-UniRule.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:UniProtKB-UniRule.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   CDD; cd11899; SH3_Nck2_1; 1.
DR   CDD; cd11903; SH3_Nck2_3; 1.
DR   CDD; cd11766; SH3_Nck_2; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 3.
DR   InterPro; IPR017304; NCK.
DR   InterPro; IPR035559; Nck2_SH3_1.
DR   InterPro; IPR035561; Nck2_SH3_3.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR19969:SF12; CYTOPLASMIC PROTEIN NCK2; 1.
DR   PANTHER; PTHR19969; SH2-SH3 ADAPTOR PROTEIN-RELATED; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF00018; SH3_1; 2.
DR   Pfam; PF14604; SH3_9; 1.
DR   PIRSF; PIRSF037874; Cytoplasmic_NCK; 1.
DR   PRINTS; PR00499; P67PHOX.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00326; SH3; 3.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF50044; SH3-domain; 3.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50002; SH3; 3.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR037874};
KW   Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR037874};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}; Translation regulation {ECO:0000256|PIRNR:PIRNR037874}.
FT   DOMAIN          2..61
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          118..177
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          210..272
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          301..395
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          79..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..101
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   396 AA;  44466 MW;  5005A0C156596806 CRC64;
     MTEEVIVVAK WDYTAQQDQE LDIRKNERLF LLDDSKTWWR VRNAANQTGY VPSNYVERKN
     SLKKGSLVKN IKDTLGLGKN KRKTSARDAS PTPSSDMEYP SNGSGGGGVV GAAERIYDLN
     IPAVVKFAYT AERDDELTLT KGSKVMVMEK CSDGWWRGSQ AGRVGWFPSN YVQEELAGAH
     DRGEDDSPRR YYEGSVGTLL ANGRAGGRGG VLHLVQTLYP FSSVTEEELN FEKGEIMEVV
     EKPENDPEWW RCRNSRGIVG LVPKNYVMVL DERPGVPSST SGSPQNRVAP ARSGRFAGRD
     WYYGNITRHQ AECILNERGE EGNFLIRDSE SSPSDFSVSL KAVEKNKHFK VQLSDGVYCI
     GQRRFNSMDE LVEHYKKAPI FTSEHGEKLY LVKALL
//