ID   A0A3Q2ZSN0_KRYMA        Unreviewed;       472 AA.
AC   A0A3Q2ZSN0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Signal transducing adaptor molecule {ECO:0000313|Ensembl:ENSKMAP00000001224.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000001224.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000001224.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Early endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004469}.
CC   -!- SIMILARITY: Belongs to the STAM family.
CC       {ECO:0000256|ARBA:ARBA00009666}.
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DR   AlphaFoldDB; A0A3Q2ZSN0; -.
DR   Ensembl; ENSKMAT00000001262.1; ENSKMAP00000001224.1; ENSKMAG00000000911.1.
DR   GeneTree; ENSGT00940000157171; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd21389; GAT_STAM1; 1.
DR   CDD; cd11964; SH3_STAM1; 1.
DR   CDD; cd17000; VHS_STAM1; 1.
DR   Gene3D; 1.20.5.1940; -; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 6.10.140.100; -; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR047492; GAT_STAM1.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR035657; STAM1_SH3.
DR   InterPro; IPR003903; UIM_dom.
DR   InterPro; IPR002014; VHS_dom.
DR   InterPro; IPR047528; VHS_STAM1.
DR   PANTHER; PTHR45929; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR   PANTHER; PTHR45929:SF2; SIGNAL TRANSDUCING ADAPTER MOLECULE 1; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF02809; UIM; 1.
DR   Pfam; PF00790; VHS; 1.
DR   PRINTS; PR00499; P67PHOX.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00326; SH3; 1.
DR   SMART; SM00288; VHS; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS50330; UIM; 1.
DR   PROSITE; PS50179; VHS; 1.
PE   3: Inferred from homology;
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          16..143
FT                   /note="VHS"
FT                   /evidence="ECO:0000259|PROSITE:PS50179"
FT   DOMAIN          211..270
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          153..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          185..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          426..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..461
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   472 AA;  52142 MW;  E935B7ED7F660A91 CRC64;
     MPLFTTNPFD QDVEKATSEM NTAEDWGLIL DICDKIGQSR TGPKECLRSI MRRVNHKDPH
     VAMQALTLLG ACVSNCGKIF HLEVCSREFA SEVSNVLNKG HPKVCEKLKA LMVEWAEDFR
     KDPQLSLISA MIKNLREQGV TFPAVGSQAA EQAKASPALV AKDPATSTNK KEEEDLAKAI
     ELSLKEQRQQ PQTSLSSLYP STSSLLSTHK SDGRKVRAIY DFEAAEDNEL TFKSGEIITI
     LDDSDPNWWK GETYQGVGLF PSNFVTADLT AEPEMMKTEK KTVQFSEDIQ VETIEPEQEP
     VYIDEDKMDQ LLQMIQSADP TDNQSDSIEL LQLEGACNQM GPLIDQKLED IDRKHSELSE
     LNVKVMEALS LYAKLMNEDP VYAMYAKLQS QQYYMQQPAS VAQQVKSVHR GSGLNMSAYV
     QSYPNPASAA GPPPCTTPAG MTQTANYSAP SGTSLAPPSE AQQAPYSEKA LL
//