ID   A0A3Q2ZTX7_KRYMA        Unreviewed;      1064 AA.
AC   A0A3Q2ZTX7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Alsin Rho guanine nucleotide exchange factor ALS2 a {ECO:0000313|Ensembl:ENSKMAP00000001724.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000001724.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000001724.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q2ZTX7; -.
DR   STRING; 37003.ENSKMAP00000001724; -.
DR   Ensembl; ENSKMAT00000001770.1; ENSKMAP00000001724.1; ENSKMAG00000001285.1.
DR   GeneTree; ENSGT00940000155861; -.
DR   OMA; CIAVYMS; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 3.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR   InterPro; IPR003409; MORN.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   PANTHER; PTHR46089:SF3; ALSIN; 1.
DR   PANTHER; PTHR46089; ALSIN HOMOLOG; 1.
DR   Pfam; PF02493; MORN; 7.
DR   Pfam; PF00415; RCC1; 2.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   SMART; SM00698; MORN; 6.
DR   SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00626; RCC1_2; 3.
DR   PROSITE; PS50012; RCC1_3; 3.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800}.
FT   REPEAT          56..103
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          104..160
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          391..442
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   DOMAIN          818..840
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          354..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1064 AA;  116494 MW;  D347C348252BDB3B CRC64;
     SSVCRPADER AVSAPERGLL HVWCSAGCSP ERALLSTPAL QVALGEHHGL VLAQGGQVFS
     FGALSWRNLS IPVSAPVLEL ALRGKTIVRV AAGGFHCGAI SEHGNVYMWG ENTAGQCGGS
     ERVSEPSPVS VVDSEGIPPA AVRVVDLACG REHSLALSAQ NELWAWGSGC QLVLGCLVAC
     GAYHSLALVL SLPAQGCNAQ SSPKTKERAP PPHCLVVDRD ELFAADDSHY CPLGVELTEA
     MRSEVNNPLF VCRKVLSEEM MIKRLQESLA AWKHNLKKGG MVQGSTAQFY SHGARLVIGG
     FDLLSCSVGG LAAWRSSSPV CLEEVRLCLE KERLSLQGQK SSSLTNIHQR WKTAAGRRRS
     LPGTPTHGRN GRVPFSVGPE EAGDGLPSLE TEVWSWGRGS EGQLGHGDQL ARLQPLCIKT
     LTGQEVIKVS AGSHHSLALT AQCQVYSWGS NMCGQLGHIN SPVTVPQQAK VRSSLTSFSK
     RCVHLVNDRV LSTDSTGGVH PEEETSSDSM GYISSVCSGG QMCASLTDLN VKGFIAAIHE
     LASSERQFYC WLSSFRRILL TPLQSVCLAL GEPCTQLFFS LWESFVHLSS LVGRHATSLS
     YFLHDAQGRD ENRLLVVVIG PNVIQTLSFF SLTNSKRINP LRHTQMMFKG VISVSLGSQQ
     TLLSQLNVPD PSVSGDGDLV SMFYWPLQQL HQYNRVLLKL TIRLLCCYQT LHHSFSLYET
     LSLSLLRKKK EAENTFIFWK SHSGKYTESL RVPHRRVVCE SSNRSLTLQN AGRFSSHWFI
     LFSDVLVHTQ VHTHTQQASS HLFAGNINFR GITTDKIFTL VASTPQEKNK WLRALNQAVD
     QVLGGGGQGS SPGVAAMSRT ATYTFTADER FRDAQYSGGW LAGRVHGRGT MKWPDGRMYK
     GNFKNGLEDG YGECVMPHKV QDKPDTYQGQ WREGRIHGFG KYKYASGEVY EGCFCNGQRH
     GYGMLSSGKL DRSSSSVFIG HWVHDKKAAY GVYDDITRGE KYIGMWLDDQ RHGSAVVVTQ
     YGVYYEGTFR DNKMAGPGLL VSEDDTVFHG EFSDDWTVSG KGNP
//