ID   A0A3Q2ZUU8_KRYMA        Unreviewed;       710 AA.
AC   A0A3Q2ZUU8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=glutamine--fructose-6-phosphate transaminase (isomerizing) {ECO:0000256|ARBA:ARBA00012916};
DE            EC=2.6.1.16 {ECO:0000256|ARBA:ARBA00012916};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000007583.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000007583.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-
CC         phosphate + L-glutamate; Xref=Rhea:RHEA:13237, ChEBI:CHEBI:29985,
CC         ChEBI:CHEBI:58359, ChEBI:CHEBI:58725, ChEBI:CHEBI:61527; EC=2.6.1.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00001031};
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DR   AlphaFoldDB; A0A3Q2ZUU8; -.
DR   STRING; 37003.ENSKMAP00000007583; -.
DR   Ensembl; ENSKMAT00000007703.1; ENSKMAP00000007583.1; ENSKMAG00000005693.1.
DR   GeneTree; ENSGT00940000158488; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity; IEA:UniProtKB-EC.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR   GO; GO:0002063; P:chondrocyte development; IEA:Ensembl.
DR   GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
DR   GO; GO:0007528; P:neuromuscular junction development; IEA:Ensembl.
DR   GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR   CDD; cd00714; GFAT; 1.
DR   CDD; cd05008; SIS_GlmS_GlmD_1; 1.
DR   CDD; cd05009; SIS_GlmS_GlmD_2; 1.
DR   Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR   InterPro; IPR017932; GATase_2_dom.
DR   InterPro; IPR047084; GFAT_N.
DR   InterPro; IPR035466; GlmS/AgaS_SIS.
DR   InterPro; IPR035490; GlmS/FrlB_SIS.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   InterPro; IPR001347; SIS_dom.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   PANTHER; PTHR10937; GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING; 1.
DR   PANTHER; PTHR10937:SF12; GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] 1; 1.
DR   Pfam; PF13522; GATase_6; 1.
DR   Pfam; PF01380; SIS; 2.
DR   SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR   SUPFAM; SSF53697; SIS domain; 1.
DR   PROSITE; PS51278; GATASE_TYPE_2; 1.
DR   PROSITE; PS51464; SIS; 2.
PE   4: Predicted;
KW   Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          2..291
FT                   /note="Glutamine amidotransferase type-2"
FT                   /evidence="ECO:0000259|PROSITE:PS51278"
FT   DOMAIN          363..502
FT                   /note="SIS"
FT                   /evidence="ECO:0000259|PROSITE:PS51464"
FT   DOMAIN          534..675
FT                   /note="SIS"
FT                   /evidence="ECO:0000259|PROSITE:PS51464"
SQ   SEQUENCE   710 AA;  79901 MW;  8ECBE83796D67F47 CRC64;
     MCGIFAYLNY HVPRTRRDIL EILLKGLRRL EYRGYDSAGV GIDGGNSKDW ESNGKSIQLI
     KQRGKVKALD EEIHKQQDID LDVEFDVHLG IAHTRWATHG VPSPVNSHPH RSDKSNEFIV
     IHNGIITNYK DLRKFLESKG YDFESETDTE TIAKLVKYMY DNRESDSISF ATLVERVIQQ
     LEGAFALVFK CVHYPGEAVV TRRGSPLLIG VRSDHKLSTD HIPVLYRSSG KDKKDKKNCN
     ALPRLDQDTC LFPVEEKAVE YYFASDASAV IEHTNRVIFL EDDDVAAVTD GRLSIHRIKR
     GAGDYPARAI QTLQMELQQI MKGNYSSFMQ KEIFEQPESV VNTMRGRVNF DNNTVTLGGL
     KDHIKEIQRC RRLILIACGT SYHAGVATRQ VLEELTELPV MVELASDFLD RNTPVFRDDV
     CFFISQSGET ADSLMALRYC KERGALTVGI TNTVGSSISR ETDCGVHINA GPEIGVASTK
     AYTSQFVALI MFALLMCDDR ISMQPRRREI IQGLRVLPDL IKEVLSLDDE IQKLATELYQ
     QKSVLIMGRG YHYATCLEGA LKIKEITYMH SEGILAGELK HGPLALVDKL MPVIMIIMRD
     HTYTKCQNAL QQIVARQGRP IVICDRDDHE TITTSCRTIK VPHGVDCLQG ILSVIPLQLL
     SFHLAVLRGY DVSPAPSVSE AKRDPSHLLQ MPRRCAELAD FKPDNATLFM
//