ID A0A3Q2ZVX5_KRYMA Unreviewed; 294 AA.
AC A0A3Q2ZVX5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Muscarinic acetylcholine receptor {ECO:0000256|RuleBase:RU361191};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000007415.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000007415.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: The muscarinic acetylcholine receptor mediates various
CC cellular responses, including inhibition of adenylate cyclase,
CC breakdown of phosphoinositides and modulation of potassium channels
CC through the action of G proteins. {ECO:0000256|RuleBase:RU361191}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361191};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU361191}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU361191}; Multi-pass
CC membrane protein {ECO:0000256|RuleBase:RU361191}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Muscarinic acetylcholine receptor subfamily.
CC {ECO:0000256|RuleBase:RU361191}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361191}.
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DR AlphaFoldDB; A0A3Q2ZVX5; -.
DR STRING; 37003.ENSKMAP00000007415; -.
DR Ensembl; ENSKMAT00000007535.1; ENSKMAP00000007415.1; ENSKMAG00000005596.1.
DR GeneTree; ENSGT00940000160394; -.
DR OMA; HNWRRER; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016907; F:G protein-coupled acetylcholine receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000995; Musac_Ach_rcpt.
DR PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR PANTHER; PTHR24247:SF180; MUSCARINIC ACETYLCHOLINE RECEPTOR M4; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00243; MUSCARINICR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU361191};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361191};
KW Postsynaptic cell membrane {ECO:0000256|RuleBase:RU361191};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Synapse {ECO:0000256|RuleBase:RU361191};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361191}.
FT TRANSMEM 38..63
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT TRANSMEM 75..98
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT TRANSMEM 113..134
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT TRANSMEM 154..180
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT TRANSMEM 200..221
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361191"
FT DOMAIN 55..294
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 294 AA; 32662 MW; 744B9A0E94421FE3 CRC64;
MAPTPELHLN SSTWLRPHGN ASSQPPIRAL YPWSTAQLIL IVMVTGSLSV LTVLGNTLVI
LSIKVNRHLR TVNNYFLLSL AAADLLIGAV SMNVYTLYQL RGRWPLGALL CDMWLVLDYA
VSGASVLNLL LISLDRYLCL TRPLSYPAWR TGRVAGLMIG AIWLLSFVLW TPAILCWQHV
GGRRAVRDGK CYTQLLANPA VTLGTTVPSF YLPALVMMGL YGRLSAASHR RLSTLRTSSP
SIKDLLLKRR AGSDRPRNHR RASMVETAGG WRHLVGAAHF LFVRTLRLTL NYFC
//