ID A0A3Q2ZZ04_KRYMA Unreviewed; 4281 AA.
AC A0A3Q2ZZ04;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=FAT atypical cadherin 2 {ECO:0000313|Ensembl:ENSKMAP00000003624.1};
GN Name=FAT2 {ECO:0000313|Ensembl:ENSKMAP00000003624.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000003624.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000003624.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR Ensembl; ENSKMAT00000003692.1; ENSKMAP00000003624.1; ENSKMAG00000002653.1.
DR GeneTree; ENSGT00940000158507; -.
DR OMA; QRRENCT; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 30.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 33.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24025; DESMOGLEIN FAMILY MEMBER; 1.
DR PANTHER; PTHR24025:SF16; FAT ATYPICAL CADHERIN 2; 1.
DR Pfam; PF00028; Cadherin; 29.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 33.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 33.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS00232; CADHERIN_1; 15.
DR PROSITE; PS50268; CADHERIN_2; 33.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..4281
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018525439"
FT TRANSMEM 3990..4007
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..152
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 153..260
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 364..459
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 460..565
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 572..687
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 710..814
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 815..919
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 920..1026
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1027..1131
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1132..1235
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1236..1347
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1375..1440
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1441..1546
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1547..1651
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1652..1749
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1750..1863
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1880..1959
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1960..2061
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2062..2162
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2163..2263
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2264..2370
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2371..2472
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2473..2576
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2577..2683
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2684..2789
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2790..2900
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2901..3006
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3007..3108
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3109..3213
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3214..3317
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3318..3422
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3423..3527
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3546..3638
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3762..3936
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 4068..4108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4236..4261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4068..4085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4240..4260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4281 AA; 473676 MW; 12C8453B5D3E2E0C CRC64;
MAASGSTHLI LLTFLLLPLA RCHRAMEKEK DGSSLSFTHY LYNVTINENS APRMYVDTPI
KMGIQLTDPV WDIKYNIVSG DEDELFQAES LSVGDFCFLR IKTRSSNSAL LNREVRDSYT
LTVEAKESTL GFQAKTKVFV HVLDTNDLKP LFYPASYNVN LREDTPLKSS VVRVSATDAD
VGSNAEFYYS FTSRAHPFAV DPFTGTVILI KKLNHTLTQK YDLTVLAEDR TKKISGVQKF
GNSARVIVNI QNVFKGAPLI TPPLKPTVSA DGNVDINAHV EAGVKPVESL NIVAGDPHNC
FEVIPLGVQG TDFQVISTKR IAWSQSPFGL NLSLQAKDRS LPSLLSPIRQ IHITANHYTP
LAFLEDTYIV TLSEFSPPKT HVVKVSVTSF HNNVTFSIKS NPDSSNFKIH GKSGIIVTTK
KFDYERKNRF EFDVVANHGE AETHIVVKII DENDNSPQFK QASYQETVAE NTPVGSSVLK
VMASDIDKGK NGFVTYAIAN SDPLPFTIDP FTGVISTSEH LDYELMKRRY HLRVWASDSG
SPFSQVSECP VTITLTNMND NIPLFERVDC NITVPLDLPV GHTIAELSAI DLDELQQLRY
IIESGNELQV FIIDAVTGVI TLKQSIPPQE GSFTLRVVAK DGKHHSEASV VRITVTNKGD
DATLRCLETG ILKQLTDKLI ESIKPVLINQ VEESFSDIHI TNRHSPKFVT SIPSSIDIAE
NHPLNSNILQ FKATDNDSGF NSKLVFAISS GNEDGCFSID TFSGELYLVC PLDRESKGLY
FLNITVYDLG IPQTSAWKFI VVNVIDVNDN PPVFDQPRYV IHVPENTVKD TVVFTCRAVD
VDTNMNGKVQ YSLLTSTDMF RVDELTGDVI VMGHLDRENS PRHDLWIKAR DQAKHDPQLF
SIVHLLVILQ DINDNPPKFE PKVYHRKVAE DVPVGTLLVW VESIDLDLGS GGLVTYNLPN
TEGGIFRLDS STGALTLERE LDFERRPAYN LTVRAVDHGF PRSLSSSCFV EIEVLDVNEN
LHKPVFTKFV YEATVMEDSA VGTSVVTLTA SDKDLSRDGV VRYHISDGSG LGLFSIDEET
GVIRTSKTLD REMVQHYWLS VYATDLGTEP LISWTHVFLK VLDVNDNAPE LSQLVYFASV
QENVDKVSSV IQVSASDVDT SSEGKLSFQM QESHKTFFNI DPKTGVISTH SALDREDKPE
HSIEVVVSDN GSPSLRSTAT VVIQVLDAND NQPKFTERLF QVKLLEQDRQ AGRKEVCRMV
AGDNDEGSNA VVTYELENSN NDGFQIDNGT GVVTVHGDFR AGSYNILTIK ATDQGNPPRS
STSRLDVEWV PRPPASTEPL TFVEPHFPFA VMETDHVTHL VGIIMMETHQ PLLWYDIIGG
DEDKDFTIQR NVGTISIARR LDAARHSNYN LTVEVTDGHQ KVTTQAYILV VDMNEHRPAF
LKSLYEVRVP EDTSPWKDIL QISAQDADPK SKLVFSIHSS LPPDSANLFH LDPKSGVLVM
KEELDFETIS VHTLIVTVLD QEIPVKRNFA KVVIQVEDCN DHSPAFLSPR YQASISNLAP
AGSEVIRVKA LDKDMGSNAD ISYSLHSGNI DNIFSIDSEL GSISLSKPLD LHPQDQFHLT
VKATDQGFPQ RSDVCSVHIR VRISDQTPPT FPSEEYLIEV NESSPPGTPV ITISASSPAA
VHYGIESGNV NGTFYINPYT GMISTNKYLD FENCESYKLK VTASTTMGAM SKTLVHIYVV
DDNDNAPVFQ QTEYLGQISE SAHINSMVMG KRNTPLVIQA SDADRDSNSL LTYQILEPEA
LKIFKIDPSM GTISLISPVD FETKTEYHLT VQVKDSGEPS LYAAEPAKVI VRVLDLNDCP
PQFTAPVYEP SFIFPVIRDT EVVRVTAHDA DSAVSYSITE GNLHNAFSIH PNTGVITVTN
VSEFRQFYQL GIRASDGLFK DSATVKINAT KLIPSDFRFE QNVYLTNVKE NLNMIKTLAA
LNVLGCYLNE PLVFSVINPM GKFAVSQTSG VLETTGIPFD REEKDVYDII VKVQDMRRPP
RTATAQVKVF IDDVNDNAPQ FLNLPFSMMI SEDTEPGDVL YQVTAIDKDL AENGSIFYSL
EEDYGLFRID PNVGDISLQR PLDFEALNKY ELIVLASDDG EPSLITMAQL TIQVRNRTNP
IFQTLLYPLK VPENVPPFTT ILHVQARNPE GYRLIYNLKE ENASKHFHID FKTGVLTVIN
PLDFESQTLH VLTVQATDSV SGASSEASIE IEVEDVNDNA PVFSQLTYSV NIAEGLPINT
SVIQLSATDK DSGRNKDLTY HIVKTEGSDA DFFQINPNSG LIVTKQVLDH EDIKHFNLKI
KAIDNGTVPL SCEALVYVNV TDVNDNTPDF VNPHYKATLD EMAKCGHIVI RIQASDPDSA
DLSNLKYKII SGNEDRYFNI NESSGIISFS NVCRKNLDPY YNLTVAVSDG VFQKTAPVNI
DMINSNKRSP YFKQSIYEAE LAENAEPGTR VIRLAAIDPD DGPHGSVDYT IINKLADEKF
AIHKDGQVVT TQPLDRENST QRVIAIKVMA KDGGGKVAFC TVKIILTDEN DNVPQFKATD
YQVSIQSTVN KGSPVITVLA YDADDGKNGD VTYTVEEAEE VTEDIIEINP LTGVVSVKES
LVGMENKIFN FKVKARDGSL PFYNSTVPVQ MKVVPPEVPL PKFTEPLYHF SAAEDFLIGT
EIGFVRADSD IPVIYSLVNG NTIESNKDKE FSIDKESGTL LLQKPIDYEK RKWYQVDVLA
QGNHNGTDVA SLVSVKIEVQ DVNDNQPVFD ASPYRAFLAE NMPAGTTVIQ VTANDPDTDT
NGLVTYTLES LPDDTLPITE VFTIDGDSGW ITTVQETDCE ATRVYRFNVV ATDHGGDVKL
SSSVLVEVMV TDQNDNPPKF TDGVYRGSVV ENLTPFEPIV SMTTTDADVS LENRLVTCYI
TDGDPLGQFA IIQEDEGQWG LIVKETLDRE TKDRYTLKVT ATDGKFEAPV TVDVHVLDIN
DNSPVCEQLM YTEGVMENLP PRMFVLKVSA SDSDVGVNGE ISYTLHGPDA NKFHLEQRTG
ELFTWAALDR EADLEYNLVV KATDGGGRSC QADVLLMIQD MNDNPPHFST SHYEVTVFDN
TTARTPISVI YATDADTGIN SEVKYSLLEG DDGYFSLDEV SGVLRLERPL TSDTPPTFEL
KVRATDRGLP LQLYSVATVT VDVVSLDDYQ PVFLSSEYTA QLPESLAVGS EVLSVSALTR
EGGGPDPIVY RIISGNEDGR FLLDSRTGLL TLVAPLDFEV FREYYLSVEG SRGKSSLSDI
TTIIINVTDA NDNPPVFAQS VYSTEISEDL TPGSLVMTVT ANDLDGPINN LLRYSIVSGD
VQQQFSIHPR SGEITVRTAL DREEIPHYSL TVQAADEGNP PLLSAVLITI TVLDVNDNKP
VFSQVNHNLY LQEGESIGSS ILQLVVKDRD TPKNGPPFSF HIISGNNERR FHVDQGGLLS
LSAPLRKKTK PFHQLKIQVT DSGHPPLSSI CVVNINVTEQ SKYPPSVVPL EVFITTAGGL
FANRVIGRLH ASDQDLQDIL TYKLVSENPD GKRFSIDSND GRIWADEHLE GGSYALNVSV
SDGKFSVWAG VRVHLWEADQ RALDSGLTLQ LDKMSPEEFL ADQWRGLQRS LAQALTLPRQ
EIHLASLQQL PHTQILEVLL VWRCMQTEPK PFDAGIMADM EDSLSLSILR VSHNGCLGAG
CPPRGCRNAV LLSGERLNHF TTARAGYITP QHTWESVCAC NESALRFDSK SYLKFLPRMD
EDSQEFRLTL RFKTFQQQGL IMSTNGPNDW GVLQVCLLLM LYRCGNLSPK TLLIRSDSVS
DGRWHDVLLE VNTTSLKLTL DQQHPASIGL MEPCRMMRFH GALLFAPLQK DSVQDLGRDA
HSFIGCLEGL KLNGEPIAAA WTGSGSRRVF GVYQCCSRTG GCDSQPCENG GICREDFCCR
KQLVGTNTVE VCSPNHCAGG FDCKVTEGTI HFILTFFLVG IFVCIRMRYV RQKKKMPVCV
QDSNGYFPTS LTKSLKADDE DSKPVEMNSM VTPTNNLDHP PFRSLRPCSQ IGSSGSGSPR
TQGPVVCSVA PNLPARPPSS SDNGSIRKGH WDREYEVYPA DPDYYGRPTV QEFPQFDIVE
DSYSTSTVDS RRNSRFGGFP FPLDRCDRRA PLPPCYSNQN LDDFLGPDGL PLPSSQCPNE
YTAISYYPTQ HTRSLDNVTG GYKRLSMRLS VAMPSYAEQA SPPSAPNAAQ PQTRAAGQNP
CHYDGTSMVG SDYGSCEEVM F
//