ID A0A3Q2ZZK7_KRYMA Unreviewed; 452 AA.
AC A0A3Q2ZZK7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=E2F transcription factor 1 {ECO:0000313|Ensembl:ENSKMAP00000008865.1};
GN Name=E2F1 {ECO:0000313|Ensembl:ENSKMAP00000008865.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000008865.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000008865.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR RefSeq; XP_017266670.1; XM_017411181.1.
DR AlphaFoldDB; A0A3Q2ZZK7; -.
DR STRING; 37003.ENSKMAP00000008865; -.
DR Ensembl; ENSKMAT00000008999.1; ENSKMAP00000008865.1; ENSKMAG00000006661.1.
DR GeneID; 108233019; -.
DR KEGG; kmr:108233019; -.
DR CTD; 1869; -.
DR GeneTree; ENSGT00940000159472; -.
DR OMA; HVMEQQI; -.
DR OrthoDB; 1761at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd14660; E2F_DD; 1.
DR Gene3D; 6.10.250.540; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR032198; E2F_CC-MB.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF43; TRANSCRIPTION FACTOR E2F1; 1.
DR Pfam; PF16421; E2F_CC-MB; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 127..192
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 69..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 452 AA; 48832 MW; 73EF56D723B33FCC CRC64;
MSETLITGQT SEDLLADFET LLNSGSINLG EDHQIVIITS PSNEGLHPAV APTSTGEILL
FATPQGPADV GVQDKRRPAL GRPPVKRKLD LDSDHQYVST TRPSTGQAPP STPAPPRVPR
HTAEKSRYDT SLNLTTKRFL NLLSQSADGV VDLNWASQVL DVQKRRIYDI TNVLEGIQLI
SKKSKNNIQW LGNRIDANLV SRHKDLQREV CDLTEAEEQL DELISKCTLQ LRLLTEDPQN
KKLGYVRCQD LRKSFDSPDQ LVMVIRAPPE TQMQVTEPSE GYQVSLKSTQ GPIDVFLCPE
DSSGVCSPVT GSSPSKINPT LVPPPSEPAE QSQSKACAAA QEVAASSPSS TSSTVTVASQ
QDASSLVLGG DTESLLGGDP FSSLGDITDF DFSPLSSSDL LNGEGLPLPL DSFINLSPPH
SHDYHFGLED HEGISELFDC DFGDLSHVLG DS
//
