ID A0A3Q3A0A0_KRYMA Unreviewed; 1895 AA.
AC A0A3Q3A0A0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Plexin-A1-like {ECO:0000313|Ensembl:ENSKMAP00000009573.1};
GN Name=PLXNA1 {ECO:0000313|Ensembl:ENSKMAP00000009573.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000009573.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000009573.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR RefSeq; XP_017266793.1; XM_017411304.1.
DR STRING; 37003.ENSKMAP00000009573; -.
DR Ensembl; ENSKMAT00000009720.1; ENSKMAP00000009573.1; ENSKMAG00000007119.1.
DR GeneID; 108233099; -.
DR KEGG; kmr:108233099; -.
DR CTD; 795761; -.
DR GeneTree; ENSGT01050000244850; -.
DR OMA; VGCEQAG; -.
DR OrthoDB; 1387371at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF35; PLEXIN-A1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 3.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 2.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1895
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018547216"
FT TRANSMEM 1244..1266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..502
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT COILED 1263..1312
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1895 AA; 212238 MW; CF17762AA0C116B7 CRC64;
MSSHLNPPLL LPFLFLLLLL SKTSTSTTPP SSSFLSFSPP EGGLTHLVVN NKTGDVYLGA
VNWIYKLSSD LTKLRSHVTG PVTDNPRCYP PPGVQSCPHE LVQTSNTNKL LLLDAAHNRL
IACGSTSQGI CQFLRLDDLF KLGEPHHRKE HYLSSVAEAG TMSGVVISPD IFGGGGKLFV
GTPIDGKSEY FPTLSSRKLM SNEENADMFS FVYQDEFVSS QLKIPSDTLS KFPTFDIYYI
YGFNSEQFVY YLTLQLDTQL TSPDASSEQF FTSKIIRLCV DDPKFYSYVE FPIGCTKDGV
EYRLVQDAFL AHPGTRLARS LGIREHEEVL FTVFAQGQKN RAKPPKESAL CLFTMRQIKE
KIKERIQSCY KGEGKLSLPW LLNKELGCIN SPLQIDDDFC GQDFNQPLGG TKAIEGIPLY
VDKDDGMTSV AAYDYRGNTV VFTGTHSGRM KKLLVNSISQ PALLYENVVV SDGNPILRDL
LFSPDHQFLY ALTDKQVTRV PVESCEQYTS CGDCLGSGDP HCGWCVLHNV CSRRDHCERA
EEAQRFTTRV EQCVHLSVHP ETISVTMSEV QLVLQAQNVP SLSAGVNCSF EDFVETEARI
YSGRIFCLSP STKDVAPITR DQGDQRIIRL YLKSKETGKK FASVLFIFYN CSVHQSCLSC
VNANFPCHWC KYRHMCTQDA SDCSFQEGRV NTSQECPQIL PSTQIYIPAG VMRPITLLAQ
NLPQPQSGQR NYECIFHIQG NTHSVPALRF NSSSIQCQKT MYDYEGSDIS DLPVDLSVVW
NGNFVIDNPF NIQAHLYKCR ALRDSCGMCL KADPRFECGW CVQDKKCSLR QECTGGGNSN
LPLQVAEGGG WMHATSGNSR CTHPKIIKLF PETGPRQGGT RVTILGENLG LQFRDIQMGV
RLGKVPCVPV EDEYVSAERI VCLLNDATGY RVQEAQVEVC VRDCINDYRA LSPRPFTFVT
PYFTRIQPSQ GPISGGTRVT IEGSYLNAGS YVSVSIGRQP CYFKRRNARE IVCDTPAGLA
PGSTSVLVDI DDAELRNPEV KFNYTEDPTV LKIEPDWSIA SGGTPLTVSG TNLATIKEPK
IRAKYGQAES FHNCTVYNNS VMVCLAPSVA DSELGFSETG TGPDEIGFYM DNVNALVVVN
ETFSYYPDPV FEPLSPSGVL ELKPTSPLIL KGRNLIPAAP GNSRLNYTVL IGETPCILTL
SESQLLCEWP NLTGQHKVTI RAGGFEYSPG TLHIYSDSLL TLPAIIGIGG GGGLLLLVII
AVLIAYKRKS RDADRTLKRL QLQMDNLESR VALECKEAFA ELQTDIHELT QELDGAGIPF
LDYRTYAMRV LFPGIEDHPV LKEMEVQANV EKALTLFGQL LTKKHFLLTF IRTLEAQRSF
SMRDRGNVAS LIMTALQGEM EYATGVLKQL LSDLIDRNLE SKNHPKLLLR RTESVAEKML
TNWFTFLLYK FLKECAGEPL FMLYCAIKQQ MEKGPIDAIT GEARYSLSED KLIRQQIDYK
TLTLHCVNPE NENAPEVTVK CLNCDTITQV KEKLLDAVYK GSPYSQRPKA SDMDLEWRQG
RMARIILQDE DVTTKIDNDW KRLNTLAHYQ VTDGSVIALV PKQNSAYNIS NSSTFTKSLS
RYESMLRTAS SPDSLRSRTP MITPDLESGT KLWHLVKNHD HSDQREGDRG SKMVSEIYLT
RLLATKGTLQ KFVDDLFETI FSTAHRGSAL PLAIKYMFDF LDEQADKHSI TDYDVRHTWK
SNCLPLRFWV NVIKNPQFVF DIHKNSITDA CLSVVAQTFM DSCSTSEHKL GKDSPSNKLL
YAKDIPNYKS WVERYYSDIS RMPAISDQDM SAYLAEQSRL HLNQFNSMSA LHEIYTYIIK
YKDELLSALQ KDEQSRRQRL RGKLEQVIDT MALAS
//
