ID A0A3Q3A0N7_KRYMA Unreviewed; 1454 AA.
AC A0A3Q3A0N7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRU {ECO:0000313|Ensembl:ENSKMAP00000009315.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000009315.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000009315.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR RefSeq; XP_017287368.1; XM_017431879.1.
DR STRING; 37003.ENSKMAP00000009315; -.
DR Ensembl; ENSKMAT00000009453.1; ENSKMAP00000009315.1; ENSKMAG00000006903.1.
DR GeneID; 108245184; -.
DR KEGG; kmr:108245184; -.
DR CTD; 563584; -.
DR GeneTree; ENSGT00940000157151; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF10; PROTEIN-TYROSINE-PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1454
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018642063"
FT DOMAIN 24..186
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 285..380
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 383..485
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 491..591
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 915..1152
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1072..1143
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1184..1447
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1363..1438
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 838..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1454 AA; 163806 MW; C97172C995A43A9B CRC64;
MHSAALLLML AARICADSTE RPTAGCTFDE DSDSGLCEYK QGQEDDFDWQ LIRTYSWLHP
TTDLLPGSFM MVNSSQHMGA QRAQLHLLPL SENDTHCIQF SYFLYSRDGH SPGALQVYIR
VNGGPKGSAV WNISGSQGHQ WHQVELAVST FWPSEYQVIF EATISDDRQG YIALDDTVLL
NYPCYKVAHF SRLGDVEVNA GQNASFQCVA TGKVSETEPF LLERRNGVVL NTSLLSRLSH
KRLMATFQVE AQRGEQDLYR CITLSPRGAA VSNFGELIVR VPPTPIAPPQ LLRAGPTYLI
IQLNTNSIVG DGPVIRREIQ YRASQSTWTE THVVGSLTYK VWHLEPDTEY QISVLLTRPG
EGGTGAPGPP LVSRTKCAEP MRALRGLTAT EIQPRQLALQ WEPLGYNLTR CHTYSLSLCY
RYSMPTGSSG GNNATVRECL SVDRNTSHFT LRDLPPFRTV HVRLALSNPE GKKESREVTF
QTEEDIPGGI APESLTFTPL DDMIFLKWEE PVEPNGLITQ YEISYQSIES SDPGINVPGP
RRTVSKLRNE TYHMFSGLHP GTTYLVSVRA RTAKGFGQTA LTEITTNISA PVFDYEDIPS
PLSESESTIT VLLRPALGRG APVSAYQVVV VEEDGSRQVR RRELGTVDCF PSPNSHNEAQ
AKGSPHYYTA ELAPSSLPEA TPFTVGDNHT YNGYWNSPLD PTKNYLIYFQ ATSNFRGETR
INCIRIARKA ACKDSKTALE VSQHAEDMGL ILGACAGGLV VLILLLGAII IIVKKGRDFY
SYPYYPRKKV AINKAAMSYR QEKSRKLSSL DCSMTEQSTL QQDEKMVHSF MDTHGCNARN
EQRSSVNESS SLLGGSPQRH CRRKSSPYHT GQLHPAVRVA DLLQHINQMK TSEGYGFKQE
YESFFNGWDV TKKKDKTKGR HDSLLSHDRH RVKLQSLLAD PSSEYVNANY IDIRINREGY
QRSNHFIATQ GPNQEMIYDF WRMVWQENCF SIVMLTKLVE IGRIKCCKYW PDDTELYGDI
KITLLKTETL AEYTVRTFAM ERRGYPAKHE VCQFHFTSWP EHGVPYHSTG LLAFLRRVKA
STPPDAGPVV VHCSMGAGRT GCYIVLDVML DMAECEGVVD IYNCVKTLCS RRINMIQTEE
QYVFIHDAIL EACLCGETAI PVSEFALTYK EMLKVDSQSN TSQLREEFQT LNSVTPHLDV
EECSISLMPR NREKNRSMDV LPPDRSLAFL ITTEGESSNY VNAALADSFL RPAAFVVTPH
PLPGTTTDFW RLVYDYGCTS VVMLNQLNQS NSAWPCLQYW PEPGLQQFGP MTVELLSRTA
DDDIIIRLFR IQNITRLQEG QLVVRHFQFL RWSPYRDVPD SKKAFLSLLA QVHNWQRECG
EGRTAVHCLN GGGRSGTFCA CTMILEMIRH HSMVDVFFAA KTLRNSKPNM VETMEQYRFC
YELAQEYLDC LEVR
//