ID A0A3Q3A1X5_KRYMA Unreviewed; 608 AA.
AC A0A3Q3A1X5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Nuclear receptor subfamily 2 group C member 1 {ECO:0000313|Ensembl:ENSKMAP00000004784.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000004784.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000004784.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, PML body
CC {ECO:0000256|ARBA:ARBA00004322}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily. {ECO:0000256|ARBA:ARBA00006421}.
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DR RefSeq; XP_017261057.1; XM_017405568.1.
DR AlphaFoldDB; A0A3Q3A1X5; -.
DR STRING; 37003.ENSKMAP00000004784; -.
DR Ensembl; ENSKMAT00000004870.1; ENSKMAP00000004784.1; ENSKMAG00000003628.1.
DR GeneID; 108229863; -.
DR KEGG; kmr:108229863; -.
DR CTD; 7181; -.
DR GeneTree; ENSGT00940000158165; -.
DR OMA; GPMSIET; -.
DR OrthoDB; 5400963at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06967; NR_DBD_TR2_like; 1.
DR CDD; cd06952; NR_LBD_TR2_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR048245; NR2C1/2-like_DBD.
DR InterPro; IPR048246; NR2C1/2-like_LBD.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24083:SF49; NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 1; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 116..191
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 349..596
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 292..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 608 AA; 66862 MW; 0D3EEEB5DCA612CF CRC64;
MDGESQRIQL VSADDNMALG HRIQIVTDQQ TGQKIQIVTA LEPSSPGKQQ FILANADYSP
GGKVILAKQE GSPNKVIFAA SDGSGVNQLL FTSPELAGQQ IQFVTEGSDQ SIKPVVEYCV
VCGDKASGRH YGAVSCEGCK GFFKRSIRKN LVYTCRGSGE CAINKLHRNR CQYCRLQRCK
ALGMKQDSVQ CERKPVEVSP REKSTNCAAS TEKIYIRKNL CSPLAATPTF VSDKETARST
SLLESSMLLN IQQPFPKLEN TILIPASSEK EDPCQGDLGT LANVVTSLAH LNKTREPSDS
GNDVMGAETL SNGDSSVTDM QGDDQTASDI TRAFDTLAKV LHPGDGSGES LETTMQLMSS
EQSGPVVELD GPLLSDGHIP FKLMMPLPVP EFLNVNYICE SASRLLFLSM HWARSIPAFQ
TLSGQDNDIN LMKACWNELF ALGLAQCSNV MNVSTILSAI INHLQTSLQE DKLSPERGKL
VMEHIWRMQE FCNSMSKLSP DSYEYAYLKA IILFSPDHPG VENIPQIESF QEKAYMELQD
YVTRMYPEDS YRLSKLLLRL PALRLISAAV TEELFFAGLI GNVQIDSIIP YILKMESTDY
NSQAVSGV
//
