ID   A0A3Q3A2I6_KRYMA        Unreviewed;       908 AA.
AC   A0A3Q3A2I6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Nuclear factor of activated T-cells, cytoplasmic 1-like {ECO:0000313|Ensembl:ENSKMAP00000005024.1};
GN   Name=NFATC1 {ECO:0000313|Ensembl:ENSKMAP00000005024.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000005024.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000005024.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q3A2I6; -.
DR   Ensembl; ENSKMAT00000005113.1; ENSKMAP00000005024.1; ENSKMAG00000003785.1.
DR   GeneTree; ENSGT00940000157616; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07881; RHD-n_NFAT; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR008366; NFAT.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR032397; RHD_dimer.
DR   InterPro; IPR011539; RHD_DNA_bind_dom.
DR   InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR   PANTHER; PTHR12533; NFAT; 1.
DR   PANTHER; PTHR12533:SF5; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1; 1.
DR   Pfam; PF16179; RHD_dimer; 1.
DR   Pfam; PF00554; RHD_DNA_bind; 1.
DR   PRINTS; PR01789; NUCFACTORATC.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS50254; REL_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800}.
FT   DOMAIN          389..571
FT                   /note="RHD"
FT                   /evidence="ECO:0000259|PROSITE:PS50254"
FT   REGION          208..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          786..878
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        246..282
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        790..839
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        849..863
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   908 AA;  98050 MW;  81CD3C3752B62B07 CRC64;
     MQDTFSPSVR PEFSFGARIA RGLLTSLSAD MKSAEEDAYN YTPNVSLSLP LGMGNPCLPT
     QYHTLQSSPV ISVSSCHQTG YGLQNDNHSV SGYYLPQGLR PNGAPALESP RIEITAYSQY
     PENEVEEGSG EDHIIKRGVN SIVTLTLPNA DGYRDPSCLS PASSVSSRSC NSDASSYESG
     FYNYDNSPQN SPWQSPCVSP RGTSSLLSCP HAVGPATGSP HHSPSTSPQI GAVAEEGWPA
     QPRGSRPNSP KYSFNGSSYH QTSCSPNQSL TPSPHGSPRV SVTDENWLAN TNQYTNSAIV
     AAINALTTDG VVDMGEGIPI KTRKTMLDPT PSMSLKVEPG GDELGPDGEL CHEDYPSRLG
     LKKENYGGGF LDVPQHPYSW HKPKPYLSPS LPALDWQLPS CSGPYNLQIE VQPKSHHRAH
     YETEGSRGAV KALSGGHPVV QLYGYMESEP LTLQLFIGTA DDRLLRPHAF YQVHRITGKT
     VSTASHEVMQ SNTKILEIPL LPENNMRAII DCAGILKLRN SDIELRKGET DIGRKNTRVR
     LVFRVHINQP NGRTVSLQVA SNPIECSQRS AQELPLVEKQ SVTSYPTTGG KMMLLTGLNF
     LPESKVVFVE KAQDGHHLWE TEAKVDKDSV KSVSGTLVVE IPPYRNQRIS SSVQVNFYVC
     NGKRKRSQYQ RFTYLPPNVP IIKTEPNDEY DSLGPVGLSM HSKPFYGQPR LTPIMPVTEP
     DSCLVGGYPP CPPLHAAMPP SSPSSSPTLH DLSPVAYSKC LPNSPTHTAP PGTVVHPIQE
     TACCPSLAHP SSPDHSSSLG MLHSQGSPNH LNSPGSQGYH HSIYANSSSS SSPVSHPSTP
     VGPVESPFVQ AYSPSQAAGS SAPAGGSPPT LLPEDVSPPS MAITVKQEPQ ELDQMYLDDG
     ELRCSCTY
//