ID A0A3Q3A3T0_KRYMA Unreviewed; 928 AA.
AC A0A3Q3A3T0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Sorting nexin 14 {ECO:0000313|Ensembl:ENSKMAP00000010966.1};
GN Name=SNX14 {ECO:0000313|Ensembl:ENSKMAP00000010966.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000010966.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000010966.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR AlphaFoldDB; A0A3Q3A3T0; -.
DR Ensembl; ENSKMAT00000011135.1; ENSKMAP00000010966.1; ENSKMAG00000008141.1.
DR GeneTree; ENSGT00950000182856; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR CDD; cd06877; PX_SNX14; 1.
DR CDD; cd08722; RGS_SNX14; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037436; SNX14_PX.
DR InterPro; IPR037892; SNX14_RGS.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 128..302
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 334..466
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 552..672
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 928 AA; 107950 MW; C8D566EDA2A71D20 CRC64;
MPRVRAFLQL IRQRVKLDRV RELGRQYPVF CFLLLLLLLS TVLLNRYIHI IMVFWSFLAG
VVTFYCSLGP ESLLPNILVS IKPKSKSFQQ ELFPQGHSCA VCGKIKCKRH RPTLLLENYQ
PWLDLKVPSK VDASLSEILE LVLENFVYPW YRDITDDEAF VDELRVTLRF FAAVLVRRTQ
KVDVASLITK KLLRVSMKHI EIISKARQRV KNTEHLQQAA LEEYGPDLHV ALRSRRDELL
YLRKLTEMLF SYILPPKAVD CRSLSLLIRE VLAGSVFLPS MDYLADPDTV NHLILIFIDN
SPPEEATEPS SAMVPFLQKY SDFRNKKPSV LKLELKEIRE QQDLLFRFMN FLKQEGAVHV
LQFCLAVEEF NDRILCPELS DSEKLMLHEE VKKIYETYCL DESIDKIRFD PFIVEEIRNI
AEGPYADVVK LQTMRCLFEA YEHVLSLLES VFTPMFCHSD EVPRLLPPVA QCPPCPRRRN
TSKRGESFAI SRIGSKIKGV FKSTTMEGAM LPSYGLVEGE DDMVEEAMMV LEDDSPMEAV
STPSTPRNLS AWSITIPYID FYDDDVKRER IPVFCIDVER NDRKAVGHET EHWSVYRRYL
EFYVLESKLT EFHGSFPDAQ LPSKRIIGPK NYEFLTSKRE EFQEYLQRLL QHPELSNSQL
LSDFLSPHSM ESQFLDKMLP DVNLGKIIKS VPSKLIKEKG QHLEPFIQAF FNSCESPKPK
PSRPELTILS PTSENDKKLF NELFKNNANR SEAAEKRHNQ NYFMEMITVE GVYDYLMYVG
RVVFRIPDWF HHLLTGGRIL FKNTLEAYAD HYLRYKLNQV VQEHRLVSLI TLLRDTVFCE
SSPPRSAQDR QRRAKRTFDD MMSYIPDFLG KCIGEEAKYE GVRLLFDGLQ QPVLNKQLTY
VLLDIAVQEL FPELNKVFTP ILSIKSFW
//
