ID   A0A3Q3A5Z0_KRYMA        Unreviewed;       826 AA.
AC   A0A3Q3A5Z0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE            EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000006289.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000006289.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class 4 subfamily. {ECO:0000256|ARBA:ARBA00034734}.
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DR   RefSeq; XP_017274720.1; XM_017419231.1.
DR   AlphaFoldDB; A0A3Q3A5Z0; -.
DR   STRING; 37003.ENSKMAP00000006289; -.
DR   Ensembl; ENSKMAT00000006397.1; ENSKMAP00000006289.1; ENSKMAG00000004779.1.
DR   GeneID; 108237645; -.
DR   KEGG; kmr:108237645; -.
DR   CTD; 26191; -.
DR   GeneTree; ENSGT00940000167346; -.
DR   OMA; GMSSEWF; -.
DR   OrthoDB; 5489271at2759; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; IEA:InterPro.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR047170; PTN12/18/22.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   PANTHER; PTHR45983; TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR45983:SF1; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 22; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800}.
FT   DOMAIN          29..294
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          208..285
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   REGION          527..566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          645..667
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          730..796
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        730..754
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   826 AA;  92655 MW;  F396BB076909A93E CRC64;
     MEQQAWILRS ILTQLERQEA ADEEAPNGIA GEFAKLKNQS TKYRIDKTFS TKTAEKQENI
     KKNRYKDIVP FDHTRVKLTI TSSKKDTDYI NASFIKGVSG SKAYIATQGP LPHTVVDFLR
     MLWEYDVQVV VMSCREFEMG KKKCEVYWPQ TQDEAFVCEP FTVHCVSEEN KGEYLTRSLR
     LTYRQSSRIL KQMHYVNWPD HGVPDTIPPI LDMLHEMRCY QPHDDFPICI HCSAGCGRTG
     ALIVIDYTWN LLRKNMISSN FSIYNLVQDM RTQRPSVVQT KEQYRLVYRT IRELFHRYME
     SMEPQNCQKE VSVCPSAVAE MIEDELSDHS EEFDLTTEHQ QLLDKESDIF LRHRSLLDSA
     LETLDDFDAA VMQWGQQQHQ PVQTFPEATQ DLNESLLLQT SQTASTVDER AEEALLLNSV
     PSLPVAEAVC HMVEDPYFDT PISSPSSEET PAEDTKWIHS PVFSAPSLLL NDQAMGPSSP
     VSVLTDEEVA PPLPERTPES FVLAEDSEVS DLCEWLSVIP PTKAAADDVG ELEENSPSPA
     PPLPERTPES FELALEPEKP QSAPPPVNLS IIGISSEWSG NSAPEVPAFP KEKGFMRSKS
     VKAGMTLSDH ALRVTSTVQP FCPARHPQNP PFLPQTMDNL VLPTSDRTQE PFTPPTEDSH
     RRSLARPHSV GSALLPQVGM SSEWDGTSQP RKFLDVVKKR SKSVRAKSSN QVEPLTAFQQ
     LTPVPVVTAQ GGSAQAEQHD VNHRPSQNTD KSGNKADKSN AKSMCRTKSL KLFRHKQRPK
     TAPPPPPAQP GATPLSVSAS STVFKFGFGN RFAKPKGPRT YPETWV
//