ID   A0A3Q3A6I3_KRYMA        Unreviewed;       845 AA.
AC   A0A3Q3A6I3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Zinc finger CCCH-type containing 12B {ECO:0000313|Ensembl:ENSKMAP00000006484.1};
GN   Name=ZC3H12B {ECO:0000313|Ensembl:ENSKMAP00000006484.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000006484.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000006484.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the ZC3H12 family.
CC       {ECO:0000256|ARBA:ARBA00010922}.
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DR   RefSeq; XP_017291008.1; XM_017435519.1.
DR   RefSeq; XP_017291009.1; XM_017435520.1.
DR   RefSeq; XP_017291010.1; XM_017435521.1.
DR   AlphaFoldDB; A0A3Q3A6I3; -.
DR   STRING; 37003.ENSKMAP00000006484; -.
DR   Ensembl; ENSKMAT00000006592.1; ENSKMAP00000006484.1; ENSKMAG00000004921.1.
DR   GeneID; 108247413; -.
DR   KEGG; kmr:108247413; -.
DR   CTD; 340554; -.
DR   GeneTree; ENSGT00940000159316; -.
DR   OMA; LEHMTSM; -.
DR   OrthoDB; 180910at2759; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd18729; PIN_Zc3h12-like; 1.
DR   Gene3D; 3.40.50.11980; -; 1.
DR   InterPro; IPR040546; Rege-1_UBA-like.
DR   InterPro; IPR040757; Regnase_1/ZC3H12_C.
DR   InterPro; IPR021869; RNase_Zc3h12_NYN.
DR   InterPro; IPR000571; Znf_CCCH.
DR   PANTHER; PTHR12876; N4BP1-RELATED; 1.
DR   PANTHER; PTHR12876:SF27; RIBONUCLEASE ZC3H12B-RELATED; 1.
DR   Pfam; PF18561; Regnase_1_C; 1.
DR   Pfam; PF11977; RNase_Zc3h12a; 1.
DR   Pfam; PF18039; UBA_6; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   3: Inferred from homology;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00723}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00723}.
FT   DOMAIN          363..388
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50103"
FT   ZN_FING         363..388
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          82..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          479..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          673..705
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        684..705
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   845 AA;  94621 MW;  34DA2B3E318A2FE7 CRC64;
     MTAWSMVEKL KMEKRPCREE NIDSREARHA ADESEDGSSS ESESEEQQPR RAQVSNSGCK
     RREPLAITKP HRQLCRSPCL DRPSFSQSST FQDFRDNDTS AASGIKPASG REYQSKMEFA
     LKLGYSGEQV EAVLHKLGTA ALINDVLAEL VRLGNKVEPE LQPCSSASTS VSRPPCVKEA
     VSPEVSVEED SVDTYDNLRP IVIDGSNVAM SHGNKEVFSC RGIQLAVEWF LEKGHKDITV
     FVPAWRKEQS RPDALITDQE ILRKLEKEKI LVFTPSRRVQ GRRVVCYDDR FIVKLAYDSD
     GIIVSNDNYR DLQNEKPEWK KFIEERLLMY SFVNDKFMPP DDPLGRHGPS LENFLRKKPV
     VPEHKKQPCP YGKKCTYGHK CKYYHPERVN QPLRSVADEL RAFAKLSAVK TMSEGALAKC
     GTGPAAVKGD INSEAKRVAP KRQSDPSIRS VACESPEALS VVRKSETNSV PSLVSALSVP
     TMQPPKSHAA GALNTRSASS PVPGSLQFAH NSLEHMSSVQ YPPILVTNSH GASVTYGDQF
     LKYDSVSDHG YYSLHSDFSN MSMSSMHNVD SFCSMEHEHV YQRNPSHCPE SCLSHSNSDS
     FSSYGDIYPS SVDSSLEESI KGQQQAPAQS RMQAFSRGFR HEALSRVQSY GPEEPKQGPR
     KQSGAHLAPR IQHAAVGARS SCPGDYPLTQ NVLPPLSSQP TRSLGMTRMD SISDSRLYDS
     NPMRQRRPPL CREQHASWDP LPCGNESFGY HSYPLSNSLM PCCERVMVRS MPDKMEQIWN
     SPWETPSAVE HQERYVIPDH QYQTYRNLCN IFPAYIVHSV MEKNPHLTDP QQLAAVIVTK
     LRSGH
//