ID A0A3Q3A753_KRYMA Unreviewed; 796 AA.
AC A0A3Q3A753;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Volume-regulated anion channel subunit LRRC8A-like {ECO:0000313|Ensembl:ENSKMAP00000012273.1};
GN Name=LRRC8A {ECO:0000313|Ensembl:ENSKMAP00000012273.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000012273.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000012273.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
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DR RefSeq; XP_017267591.1; XM_017412102.1.
DR AlphaFoldDB; A0A3Q3A753; -.
DR STRING; 37003.ENSKMAP00000012273; -.
DR Ensembl; ENSKMAT00000012457.1; ENSKMAP00000012273.1; ENSKMAG00000009227.1.
DR GeneID; 108233554; -.
DR KEGG; kmr:108233554; -.
DR CTD; 557928; -.
DR GeneTree; ENSGT00940000154043; -.
DR OMA; HNVQEID; -.
DR OrthoDB; 55205at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF3; LEUCINE RICH REPEAT CONTAINING 8 VRAC SUBUNIT A; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00369; LRR_TYP; 8.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 4.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 30..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..326
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
SQ SEQUENCE 796 AA; 93070 MW; B8881F9967558D91 CRC64;
MIPITELRYF VDTQPAYRIL KPWWDVFTDY ISIVMLMISV FGGTLQITQD KMICLPCKWV
INGTCKKNFS SSSSMPLFLE PKGIQYDLDR HQYNYVDAVC YENRLHWFAK YFPYLVLLHT
LIFLACSNFW FKFPRTSSKL EHFVSILLKC FDSPWTTRAL SETVVEESDP KPMKMNGSMD
HHKASVISED VEASVPMLQR TKTRFEQGIV DRTETGVLDK KEGEQAKALF EKVKKFRIHV
EEGDIVYRLY IRQTIIKVIK FIFIICYTGY YVHDIKFSVD CSVNIESLTG YSVYRCAHPL
ATLFKILACF YISLVVVYGL ICMYTLCWML RRSLKKYSFE SIREESSYSD IPDVKNDFAF
MLHMIDQYDP LYSKRFAVFL SEVSENKLRQ LNLNNEWTLD KLRQRITKNS QEKLELHLFM
LSGIPDTVFD LMELEVLKLE LIPDITIPPI IAQLINLREM WLYHTPAKIE APALAFLREN
LKSLHIKFTD IKEIPLWIYS LKSLSELHLT GNLSAENNRY IVIDGLRELK RLKVLRLKSN
LTKLPQVVTD VGMHLQKLSI NNEGTKLMVL NSLKKMVNLT ELELIRCDLE RIPHSIFSLH
NLQEIDLKDN NLKTIEEIIS FQHLHRLISL KLWYNQIAYI PIQIGTLINL EKLYLNRNKI
EKMPSQLFYC RKLRVLDLSH NNLTYIPTDV GFLQNLQYLA VTANRIETLP NELFQCKKLR
TLNLGNNCLQ SLPSRFGELT SLTQLELRGN RLECLPVELG ECRQLKRSGL VVEEDLFNTL
PSEAKEQLWK ADKEQT
//
