ID A0A3Q3A8F9_KRYMA Unreviewed; 411 AA.
AC A0A3Q3A8F9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Protein artemis {ECO:0000256|ARBA:ARBA00039759};
DE AltName: Full=DNA cross-link repair 1C protein {ECO:0000256|ARBA:ARBA00042677};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000012753.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000012753.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
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DR RefSeq; XP_017296782.1; XM_017441293.1.
DR AlphaFoldDB; A0A3Q3A8F9; -.
DR STRING; 37003.ENSKMAP00000012753; -.
DR Ensembl; ENSKMAT00000012943.1; ENSKMAP00000012753.1; ENSKMAG00000009568.1.
DR GeneID; 108251112; -.
DR KEGG; kmr:108251112; -.
DR CTD; 64421; -.
DR GeneTree; ENSGT00940000157779; -.
DR OMA; NVCYSTH; -.
DR OrthoDB; 23465at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd16297; artemis-SNM1C-like_MBL-fold; 1.
DR Gene3D; 3.40.50.12650; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR PANTHER; PTHR23240:SF38; PROTEIN ARTEMIS; 1.
DR Pfam; PF07522; DRMBL; 1.
DR Pfam; PF12706; Lactamase_B_2; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800}.
FT DOMAIN 26..175
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF12706"
FT DOMAIN 240..342
FT /note="DNA repair metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF07522"
SQ SEQUENCE 411 AA; 46877 MW; DE1CBBBDBB9ADA92 CRC64;
MSSFAGRMKE YPTVSLDRFD RENLHAQAYF LSHCHKDHMK GLKGPLLKRK LQFSRTVRLY
CSFVTKELLL NNPKYAFWEE YIVPLELESP TQISLVDEAS GQKEEVVVTL LPAGHCPGSV
MFLFEGCRGN VLYTGDFRLA VGDASRMEHL HSGSRVKDIQ SIYLDSTFYD PRFYQIPSRE
VCLRGISELI GNWISQSSHH VVWLNCKAAF GYEYLFTNLG DEFNTQIHVK NLAMFKKMPE
ILSYVTTDRR TQIHACRHPK DEEFFQGNRL PCGGTAADGT PLRIISIKPS TMWFGERTKR
TSVIIKTGGS SYRACFSFHS SYSEIKDFLS YLQPVNIYPS VVPIGRSLQD VTQLLRTMCR
KRSDEAAFVY KPLGVLKRSR LQRASDGNTK RSTTTKTQTC TDRVTEGCSV K
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