ID A0A3Q3A9C1_KRYMA Unreviewed; 1056 AA.
AC A0A3Q3A9C1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Integrin alpha-3-like {ECO:0000313|Ensembl:ENSKMAP00000013093.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000013093.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000013093.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_017274060.1; XM_017418571.1.
DR AlphaFoldDB; A0A3Q3A9C1; -.
DR STRING; 37003.ENSKMAP00000013093; -.
DR Ensembl; ENSKMAT00000013293.1; ENSKMAP00000013093.1; ENSKMAG00000009831.1.
DR GeneID; 108237256; -.
DR KEGG; kmr:108237256; -.
DR CTD; 100331874; -.
DR GeneTree; ENSGT00940000157746; -.
DR OMA; RYNHTGA; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0033334; P:fin morphogenesis; IEA:Ensembl.
DR GO; GO:0060047; P:heart contraction; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0060297; P:regulation of sarcomere organization; IEA:Ensembl.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF89; INTEGRIN ALPHA-3; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 26..1056
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5018382029"
FT TRANSMEM 995..1019
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 31..96
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 290..351
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 352..407
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 411..473
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 458..611
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 612..756
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 769..985
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1056 AA; 117436 MW; 31D69993B552F4F4 CRC64;
MLFPRLSALL CAVLAAHHGT RTCSGFNIDA RFPVIKEGKT KGSFFGFSVA LHEQTKGSKK
YLLLAGAPKD KAISLQNVNE TGAVYSCPIT TDPTDCTRMD LVSTTSSSEM VEGMWLGVTV
ASQRSLPDGR VLACGHRYVK IIQGGSEDQR RMIGKCFVRS NDLTFDNSDE WQTNTYQVCY
PFSDMEGEGL CNMGISAGLT DTDVYAGATG SNWWRGNVYV TWRNPLDVFD SQTKKFEDLK
NRDSYIGYSI LEEKKLLSHD DYTVVTGAPR DESKGAVLFG TKTAYDNKLI LIKTILGEQV
GSYFGSCLAA TDLNNDDWND LIVGAPFYFD RNKDQEGAVY IFMNENGSFQ NTATVVLKGP
SFSAFGFAVA AIGDVNQDGF QDFAVGAPFH ETGKVYIWMG SKKGISREPS QVIEGKSVGN
GLFHTFGYSI SGGLDMDDSS YPDILVGSLD DRIALLRARP VIHLTKTFTA EPKIVDPSQC
LPNNPCISVI LCMSFTLSNG KKDFKKNITV DYMVEADMER IRSHRVSFEN GEDTYFGSMS
LPSSVPICQT LKLNVKTPVK DKLEPVVFSV NMSLQEPNPK IRRSLQNLDS FPILSQEQKL
TQRAEINFLK DCGLDNKCSS NLQMTAQFAD NERNAYPRKN NIQVLQFNSS VKKISVLVEV
TNLPSSGRQA EDAHQTMLNI FFSDELQFST VRNNDVDCTF NYTVSCELGN PLKGNEKVRL
QIVFETSGID LYTKEIEAQL ILSTVSVQSD LKPVSLVLLI ENTIVPIFSI INPLQQTTFG
GTVMGEFAMQ NTSDVGSLVE FTFIVNTIQS LGDMGTLAVE FQWPFEVTNG KWLLYLTQIV
VTGESEMECN PSGKVVNELN LTLSKSKSKR TKRQTGEDDA EETIQHRSVE PQAAITLLPH
RKKSYLLDCS KGTANCVTFT CPLLNMSTSA KIYVRSRLWN STMLEDYPNA LRVSVTGQAT
LKLITDKPTI KMDNQTRSFT VEIEPEEEAE IPYELPLWII ISSAVAGIVL LAIIILIMWK
CGFFQRASRR EMYEAKAQKA EMKIQPSETE RLTEDY
//
