ID   A0A3Q3A9T7_KRYMA        Unreviewed;       749 AA.
AC   A0A3Q3A9T7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Transcriptional repressor p66-alpha-like {ECO:0000313|Ensembl:ENSKMAP00000007794.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000007794.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000007794.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; A0A3Q3A9T7; -.
DR   STRING; 37003.ENSKMAP00000007794; -.
DR   Ensembl; ENSKMAT00000007917.1; ENSKMAP00000007794.1; ENSKMAG00000005852.1.
DR   GeneTree; ENSGT00390000004097; -.
DR   OMA; RTDCNDR; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 6.10.250.1650; -; 1.
DR   InterPro; IPR040386; P66.
DR   InterPro; IPR032346; P66_CC.
DR   InterPro; IPR000679; Znf_GATA.
DR   PANTHER; PTHR13455:SF3; TRANSCRIPTIONAL REPRESSOR P66-ALPHA; 1.
DR   PANTHER; PTHR13455; TRANSCRIPTIONAL REPRESSOR P66-RELATED; 1.
DR   Pfam; PF00320; GATA; 1.
DR   Pfam; PF16563; P66_CC; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022771};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          226..266
FT                   /note="Transcriptional repressor p66 coiled-coil MBD2-
FT                   interaction"
FT                   /evidence="ECO:0000259|Pfam:PF16563"
FT   DOMAIN          496..532
FT                   /note="GATA-type"
FT                   /evidence="ECO:0000259|Pfam:PF00320"
FT   REGION          1..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          262..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          337..376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          393..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          558..579
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..50
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..82
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..118
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..144
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        177..193
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..300
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..352
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   749 AA;  80587 MW;  9C6F2EF5A9F0E4AE CRC64;
     MSEEAVRQTR SQKRALEREA APQSVELSNA DNDSKKPKLD PSEPPKGEQT KPKPDVLPAQ
     DIGSWTRPGS DHEKENENEQ EPEQNRLPLS LALPLTSQPM KDDQDQTQRQ QAAEPSSDNR
     TDCNDRDSKT KMEPAMDTRS RVRQTEPKAS SGMLAAGEVK ATIKVEVQTE QPVDMSTTRG
     IKKEKRPPSP EDDDDVIILS DNDSPSPPMN GLSHFKELDT DLLMKSSPEE REHIIKQLKE
     ELRLEEAKLV LLKKLRQSQI QRDNLQKPSG LSGSSAPPPL IRGTIASNKG SQQILTGRSS
     GTVIPPPLVR GGQQVSSKHG SQIIMPPLVR GAQQIQALRQ QQQQQQLAAT GGSGSGPPPL
     LLGPRTSAPA GQGQRGMVQS GLIRVGSSAN ALSSQSGLKG SSGSSGVSVV GVNDSPASRQ
     AAAKLALRKQ LEKTLLEIPP PKPPAPEFNF LPSAANNEFI YLVGLEEVVQ NLLDTIHRGK
     TGVPLSKANT RDPFICTQCN TDFTCRWRQD KAKGGAVLCE DCMSSNQKKA LKAEHTNRLK
     AAFVKALQQE QEIEQRIIQQ ASSPVSHSTS SSSSAASSLK AEQLVSQQLK QARVSSLQHH
     HQASRGANII HHHSIKQSSQ GHLSHGVSSV GMRGVPHSFS SSSQLQSAVA AAALVSRPGK
     HAHVSHRSVQ SSKVSSSGIV GGRNVSGGSA SSTAWKKQSN SNAGVTMAYV NPSLTGHKTS
     ATVDARQREY LLDMIPSRSS ISQTANTWK
//