ID A0A3Q3AA37_KRYMA Unreviewed; 137 AA.
AC A0A3Q3AA37;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Somatoliberin {ECO:0000256|ARBA:ARBA00040782};
DE AltName: Full=Growth hormone-releasing factor {ECO:0000256|ARBA:ARBA00042164};
DE AltName: Full=Growth hormone-releasing hormone {ECO:0000256|ARBA:ARBA00041953};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000007914.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000007914.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: GRF is released by the hypothalamus and acts on the
CC adenohypophyse to stimulate the secretion of growth hormone.
CC {ECO:0000256|ARBA:ARBA00037623}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR AlphaFoldDB; A0A3Q3AA37; -.
DR STRING; 37003.ENSKMAP00000007914; -.
DR Ensembl; ENSKMAT00000008039.1; ENSKMAP00000007914.1; ENSKMAG00000005945.1.
DR GeneTree; ENSGT00950000183154; -.
DR OMA; CCLVMSV; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR046963; VIP/GHRH-like.
DR PANTHER; PTHR11213; GLUCAGON-FAMILY NEUROPEPTIDE; 1.
DR PANTHER; PTHR11213:SF6; SOMATOLIBERIN; 1.
DR Pfam; PF00123; Hormone_2; 1.
DR SMART; SM00070; GLUCA; 1.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..137
FT /note="Somatoliberin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018677731"
FT DOMAIN 66..88
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
SQ SEQUENCE 137 AA; 15626 MW; 6419C652BCFEE1B6 CRC64;
MMGKAALLLF CCLVVSLSGS PLYPSIRFGQ RDTSILMTSS IKNPEVQLDK DTRPLRDRAE
LRSERHADAI FTNSYRKVLG QISARKFLQT IMGKRLGDES YMKRQSDIYE GTFKEDLTSI
QSDQRYRGVQ GSVTRPR
//
