ID   A0A3Q3ABE1_KRYMA        Unreviewed;       889 AA.
AC   A0A3Q3ABE1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Solute carrier family 12 member 3 {ECO:0000313|Ensembl:ENSKMAP00000008444.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000008444.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000008444.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
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DR   AlphaFoldDB; A0A3Q3ABE1; -.
DR   STRING; 37003.ENSKMAP00000008444; -.
DR   Ensembl; ENSKMAT00000008572.1; ENSKMAP00000008444.1; ENSKMAG00000006312.1.
DR   GeneTree; ENSGT00940000155044; -.
DR   OMA; PWMITEQ; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   GO; GO:0035844; P:cloaca development; IEA:Ensembl.
DR   GO; GO:0039023; P:pronephric duct morphogenesis; IEA:Ensembl.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR002948; SLC12A3.
DR   InterPro; IPR004842; SLC12A_fam.
DR   NCBIfam; TIGR00930; 2a30; 1.
DR   PANTHER; PTHR11827:SF9; SOLUTE CARRIER FAMILY 12 MEMBER 3; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF03522; SLC12; 2.
DR   PRINTS; PR01230; NACLTRNSPORT.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        25..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        56..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        102..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        147..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        174..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        227..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        393..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        451..468
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          28..500
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          536..657
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          686..888
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
SQ   SEQUENCE   889 AA;  98387 MW;  BFE491477035AB3A CRC64;
     MEGDTSEEEE DDQTELSSEP TRFGWIQGVM IRCMLNIWGV ILYLRLPWIT AQAGIGLTWA
     IVLLSSCITG ITGLSTSAIA TNGKVKGGGT YFLISRSLGP ELGGSIGLIF AFANAVAVAM
     HTVGFSETVT DLMRENGAVM VDRTNDIRII GIITVTFLLG ISMAGMAWES KAQILFFLVI
     MVSFASYIVG TIMPASQEKQ AKGFFSYQAS IFATNFVPDW RGPEGSFFGM FSIFFPSATG
     ILAGANISGD LKNPAVAIPR GTLMAIFWTT VSYLIITATI GSCVVRDASG LINDTLTSSI
     DSCVGVSCQY GWDFTPCITN NTCKFGISNY YQAMSMVSAF SPLITAGIFG ATLSSALACL
     VSAPKVFQCL CKDHLYPLIG FFGKGYGKNN EPLRSYLLTY IIAACFIIIA ELNTIAPIIS
     NFYLCSYALI NFSCFHASIT NSPGWRPSFR FYSKWLSLLC AVCCVVIMFL LTWWAALIAI
     GVVLFFLGYT LYKKPAEKLG TQMKNNELSS ELNISVSVCE CFRPQCLVLT GPPSSRPALV
     DLVNCFTKNL SLMMCGNVVT ADSSPSVVEK ASSNSHVFWL NQRKIKSFYR GVVAEELRSG
     VNMLLQGAGL GRIKPNVLLM GFKKAWRIHD KLIRYLYGVC IVRLKEGLDV SNPSQSHGEC
     SLILNRTHCL NECNATIKLL TGAAPSTIFQ KKQEKKTIDV YWLSDDGGLT LLLPYLLTRR
     KRWARCKVRV FVGGETDKKE AQKEEVLSLI KKFRLGFHDV EVLPDIYQTP QSVNVHHFES
     MIRRFKLDSN PKQESDSEPP RQQNAPWMIT EQDLERNMAK SLRQIRLNEV LQDYSRDAAL
     IVITMPVGRR GVCPSSLYLA WLDILSRDLR PPVLMVRGNQ ESVLTFYCQ
//