ID A0A3Q3AD06_KRYMA Unreviewed; 491 AA.
AC A0A3Q3AD06;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Fascin {ECO:0000256|PIRNR:PIRNR005682};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000014458.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000014458.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR005682}.
CC -!- SIMILARITY: Belongs to the fascin family.
CC {ECO:0000256|ARBA:ARBA00007415, ECO:0000256|PIRNR:PIRNR005682}.
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DR RefSeq; XP_017280777.1; XM_017425288.1.
DR AlphaFoldDB; A0A3Q3AD06; -.
DR STRING; 37003.ENSKMAP00000014458; -.
DR Ensembl; ENSKMAT00000014671.1; ENSKMAP00000014458.1; ENSKMAG00000010856.1.
DR GeneID; 108241262; -.
DR KEGG; kmr:108241262; -.
DR CTD; 798075; -.
DR GeneTree; ENSGT00950000183157; -.
DR OMA; IICGAEK; -.
DR OrthoDB; 5484756at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR CDD; cd00257; Fascin; 4.
DR Gene3D; 2.80.10.50; -; 4.
DR InterPro; IPR008999; Actin-crosslinking.
DR InterPro; IPR010431; Fascin.
DR InterPro; IPR022768; Fascin-domain.
DR InterPro; IPR024703; Fascin_metazoans.
DR PANTHER; PTHR10551; FASCIN; 1.
DR PANTHER; PTHR10551:SF24; FASCIN-2; 1.
DR Pfam; PF06268; Fascin; 4.
DR PIRSF; PIRSF005682; Fascin; 1.
DR SUPFAM; SSF50405; Actin-crosslinking proteins; 4.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005682};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800}.
FT DOMAIN 22..132
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 143..253
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 265..374
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 389..491
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
SQ SEQUENCE 491 AA; 54589 MW; 641E869C50A1B780 CRC64;
MPTNGINRAL KLQFGLINYG SRYLTAEAFG FKVNASGISL KKKQIWTLEQ DEQDGQVVFL
RSHLGRYLAS DKDGKITCGA EKPDPECRFL IVPQSDGRWA LQSEPYQRYF GGSADYLSCF
AQAIGEQELW AVHLALHPQA SLLSVARKRY AHLSASDGEI SVDSNIPWGV DSLVTLVYQD
GKYNLKTCDS RFLSNDGKLV KENNSTTSFT LELKSGKLAF KDCDGKYLTP VGPTGTLRSG
RCSKPGKDEL FDLEESHPQV VFQAANKRFV SVKQGVSISA NQDVETDMET FQMEIDKESK
KSMFRTNGGS YWTLVTHGEI QSTATDVEVN TMFDIEWRGH RVALKASNGK YVCTKKNGQL
SAVSDTVGDD ELFLMKLINR PMLILRGENG FVCHHKSSNT LDANRSVYDI FSLIFNNGAY
NIKSVNGMFW YVSSSGLVSS DGEKSEDFFL EFPEHGRIAI KGSNEKYLRG DQGGTLMCDG
ASLDASCLWE Y
//
