ID A0A3Q3AE15_KRYMA Unreviewed; 847 AA.
AC A0A3Q3AE15;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Lysine demethylase 7A {ECO:0000313|Ensembl:ENSKMAP00000014833.1};
GN Name=KDM7A {ECO:0000313|Ensembl:ENSKMAP00000014833.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000014833.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000014833.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SIMILARITY: Belongs to the JHDM1 histone demethylase family. JHDM1D
CC subfamily. {ECO:0000256|ARBA:ARBA00006942}.
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DR RefSeq; XP_017267163.1; XM_017411674.1.
DR AlphaFoldDB; A0A3Q3AE15; -.
DR STRING; 37003.ENSKMAP00000014833; -.
DR Ensembl; ENSKMAT00000015050.1; ENSKMAP00000014833.1; ENSKMAG00000011120.1.
DR GeneID; 108233298; -.
DR CTD; 321248; -.
DR GeneTree; ENSGT00940000158039; -.
DR OMA; PWEEDIT; -.
DR OrthoDB; 2784357at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd15640; PHD_KDM7; 1.
DR Gene3D; 1.20.58.1360; -; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR041070; JHD.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR PANTHER; PTHR23123:SF15; LYSINE-SPECIFIC DEMETHYLASE 7A; 1.
DR PANTHER; PTHR23123; PHD/F-BOX CONTAINING PROTEIN; 1.
DR Pfam; PF17811; JHD; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 5..56
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 198..354
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 567..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 95045 MW; 2818EC225CE6C0BA CRC64;
MAAAPLYCVC RQPYDVSRFM IECDICKDWF HGSCVQVEEH HAVDIDVYHC PNCDVKHGPS
LMKKRNNWHR HDYTEPNDGL KPVQAGTSVF IKKLQNRTFP GAEEIMIRMR GEQVTTRFLE
RHGFNYPIMI TEMEGLGLKL PPPTFSVKDV VQYVGGDKVI DVIDVARQAD SKMKLSEFIK
YFTKPHRPKV LNLISLEFSD TKMSELVEVP DVAKKMSWVE NYWPDDSFFP KPFVQKYCLM
GVKDSYTDFH IDFGGTSVWY HVLWGEKVFY LIKPTPANLA LYEAWSSSPN QSEVFFGDKV
DKCYKCVVPQ GTTLLIPTGW IHGVLTSQDC MAFGGNFLHN LNIGMQLRCY EMERRLKTPD
LFKFPYFEAI CWYVAKNLLE MLKELREDSC PPSTYLVDGV KALIGALRTW LKREVTEPSS
EVPDNIRPNH LIKELTKEIR YLEEEPLSGG KPVKSQGCGA SSGMNGCLTT RSLERLCQAR
QARRAARRLR EQQRQAPKVP SNLDILEQHT REVLKRLEVG PLEEDPGFCA KVHGKFNKVS
TASAAAVAES LEDNHLRLMM VNGRIIRRPE SSPVKTEGEQ SSAGHSPTKS CVAVKLEKTP
GGQEQRSAAE KATLLRGLET VKNELREDAS GHSSVSDVES DSDSPTERKA SSSSSSSSDD
DSASSQEEEE ERGLSQQAGS GHTIELDPSG QALRHKHKPL KRERPTSPST EEAIQGMLSM
AGLLCSSKPG EVTSPREPWW SSPSQRSLQE SHPHQHRLQG GNSPMDSQGN SSSEAWDNQG
LPSPETDYQY CDPSMSPPLH PSKRHAPNPP PVSNQATKGK RPKKGMATAK QRLGKILKLN
RHSHVFV
//
