ID A0A3Q3AFX9_KRYMA Unreviewed; 684 AA.
AC A0A3Q3AFX9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Small conductance calcium-activated potassium channel protein 1-like {ECO:0000313|Ensembl:ENSKMAP00000015523.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000015523.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000015523.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_017282352.1; XM_017426863.1.
DR AlphaFoldDB; A0A3Q3AFX9; -.
DR Ensembl; ENSKMAT00000015747.1; ENSKMAP00000015523.1; ENSKMAG00000011606.1.
DR GeneID; 108242172; -.
DR KEGG; kmr:108242172; -.
DR GeneTree; ENSGT00950000182904; -.
DR OrthoDB; 4200919at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0016286; F:small conductance calcium-activated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR004178; CaM-bd_dom.
DR InterPro; IPR036122; CaM-bd_dom_sf.
DR InterPro; IPR015449; K_chnl_Ca-activ_SK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR10153; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL; 1.
DR PANTHER; PTHR10153:SF40; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 3; 1.
DR Pfam; PF02888; CaMBD; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR Pfam; PF03530; SK_channel; 1.
DR PRINTS; PR01451; SKCHANNEL.
DR SMART; SM01053; CaMBD; 1.
DR SUPFAM; SSF81327; Small-conductance potassium channel; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 261..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 536..612
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000259|SMART:SM01053"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 77488 MW; 02A174BDB6ACA92D CRC64;
MDHSPSMTST VVDGDDLEDH RPLLPPRMVA PSQVYSPQCG IHHTVQTSID HTVWLDRTQA
LATTPLYNGH LYVTATPRST RRREKIKSKE KKCEKRSGEC RQTPGPKERN HQSKAKGAGS
NRLQEKVTSF TDVPISPCGS PFKGPPSRSN LDVRDVDGRG YRKSGNVSLE MHDRQSLPEI
IITSKDENLQ QQNKASHYEQ RPGEAKGSLP GLERFSRSPG SSPQVSPKHK EDPQKDPYWR
THNIGWRLVH RRALFLRRQR LNDSALAVGI FGVVMMVMET ELSWSIYSKS SIYSLTLKSV
ISISTLLLLG LIMAYHCCEV QLYVHDIGAE DWRIAMTTDR IALIALELAV AAIHPYPVGL
QAYFQKTPTR TTLSETELEI MLALPMFLRL YLLGRAMMLH SRLFTDTASR SIGALNKIHY
NTRFVGKTLM TTYPGTVLMI FSVSLWIVAA WGLHVCERHH NYRDLSSNYM EALWMVSVTF
LSIGYGDVVP HTYCGRSICL LTGIMGAGCT VLVVAVVARK LELTRAEKHV HNFMMDSHIS
KRIKIAAANV LRETWLIYKH TKLSRERDHT RVRMHQRKLL LAIHQLRRVK MEKRILADQG
NTLVDLCKMQ SLMYDTLAEV QGCRGELDSH IHSLEKHVEE LREGFRSLMP LLSSTLSTQN
SSIRHLLRER EVKSECASAS GADK
//
