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Database: UniProt
Entry: A0A3Q3AGP5_KRYMA
LinkDB: A0A3Q3AGP5_KRYMA
Original site: A0A3Q3AGP5_KRYMA 
ID   A0A3Q3AGP5_KRYMA        Unreviewed;       405 AA.
AC   A0A3Q3AGP5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Microphthalmia-associated transcription factor-like {ECO:0000313|Ensembl:ENSKMAP00000015305.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000015305.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000015305.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the MiT/TFE family.
CC       {ECO:0000256|ARBA:ARBA00008289}.
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DR   RefSeq; XP_017291319.1; XM_017435830.1.
DR   AlphaFoldDB; A0A3Q3AGP5; -.
DR   STRING; 37003.ENSKMAP00000015305; -.
DR   Ensembl; ENSKMAT00000015526.1; ENSKMAP00000015305.1; ENSKMAG00000011451.1.
DR   GeneID; 108247580; -.
DR   KEGG; kmr:108247580; -.
DR   CTD; 30080; -.
DR   GeneTree; ENSGT00940000156326; -.
DR   OMA; DLYQHSS; -.
DR   OrthoDB; 3061893at2759; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
DR   GO; GO:0061386; P:closure of optic fissure; IEA:Ensembl.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:Ensembl.
DR   GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
DR   GO; GO:0045636; P:positive regulation of melanocyte differentiation; IEA:Ensembl.
DR   CDD; cd18926; bHLHzip_MITF; 1.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR021802; MiT/TFE_C.
DR   InterPro; IPR031867; MiT/TFE_N.
DR   PANTHER; PTHR45776:SF4; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; 1.
DR   PANTHER; PTHR45776; MIP04163P; 1.
DR   Pfam; PF11851; DUF3371; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          189..242
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   REGION          39..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          367..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          235..276
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        378..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   405 AA;  45040 MW;  C1CBA11C3A049552 CRC64;
     MLEMLEYSHY QVQSHLESPT KYHIQQAQRQ QVRQYLSSTL GGKAGGQCPN QPPEHSMPPG
     PNGSAPNSPM ALLTLGSNCE KEMDDVIDDI ISLESSYNED VLGLMDPALQ INSPLPVSGN
     LLDVYNQGLP LPGLSISNSC ASNIKREFTA PGMKQVLDKS GSCGQFESYQ RPEGFPVEAE
     VRALAKERQK KDNHNLIERR RRFNINDRIK ELGTLIPKSN DPDMRWNKGT ILKASVDYIR
     KLQREQERAK ELECRQRKLE HTNRHLMLRI QELEIQARAH GLTVVSSPSV CTSELMARAI
     KQEPILGDCP SDLYQHSCGP DMSPPTTLDL NNGTITFDQI PADTGDPDPY GNSRTCKMKE
     LMRDNTLGLI SPSDPLLTAM SPDVSNNASS NHSSSSSMEE KEHSC
//
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