ID A0A3Q3AI15_KRYMA Unreviewed; 1278 AA.
AC A0A3Q3AI15;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=SH3 and multiple ankyrin repeat domains protein 1-like {ECO:0000313|Ensembl:ENSKMAP00000015795.1};
GN Name=SHANK1 {ECO:0000313|Ensembl:ENSKMAP00000015795.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000015795.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000015795.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000256|ARBA:ARBA00034105}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q3AI15; -.
DR Ensembl; ENSKMAT00000016021.1; ENSKMAP00000015795.1; ENSKMAG00000011216.1.
DR GeneTree; ENSGT00940000153561; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09506; SAM_Shank1_2_3; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24135:SF3; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 1; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 107..166
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 206..300
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1215..1278
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 22..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..436
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..640
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..756
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..803
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..934
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1098..1118
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1161..1183
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1278 AA; 138753 MW; C23BFBBF3CB040E1 CRC64;
VARRKDSAHT LPLPLLHSHP LLRANSDNTM TQSDPLALPN KSATNPNPGQ VQTTFSSPAD
LCVVRFDSCM SFSRFCRASA GKDFFSLHSA TSAGSSGGQM KRMYSAVPGR VYVATRAHSA
GGDKELSLNK GDKVKVLSIG EGGYWEGTVK GRTGWFPSDC VQELPAPSKE KETRGEKAKR
KLFRNVTVGA YDGNDGPSDY IIKEKTVLLQ KKDNEGFGFV LRGAKAQTPI EEFTPTPAFP
ALQYLESVDE GGVAWRAGLR MGDFLIEVNG QNVVKVGHRQ VVNMIRQGGN SLMVKVVMVA
RNPELEDTAR KRAPQQTKRL TPPAIALRSK SMTSELEDMG KMTERQPYEQ QSSASIVQTG
PGFGYNQAHF QPGHGPQHAV MMRQKSIGVT EEERQYLHPP AMKLARSLSV PGPEDIPPPP
NTSAPEPPLS AGPYPSRGPA MPIPPISQAH YQFHSQPGHP TQAPWERGGP GAMNQQAIVP
TLRRQSDGLC IREPEVPRRG GGKMGGLRRG YSSATPPTSA KPKTQQAQQH PPQFSNREQG
GGVGRGMARR GGRGALIKQS KVEDGLSSIP IPTIIVKAPS TSSSGRSSQG SSMEAEPSQD
TEDQPSREAG PDSSSATFGG GPRKERERLK DIRRKSASFF LSSEEDIQGE AGVPTPRLRP
SKSIDEGMFS GDNYINCSSS MPPAFGLPEY SSPILSQDGQ PKSAPSVYGA QPATTFIHPL
TGKVLDPSSP LGLALAARER ALKDDRRTRR EDRQFGRQLS TVGSFPTPVQ TPTPSLFRER
EVYDSKPAPP IQPPPPPAQP APRRPSYLQM ENTPNTSYIP QYTVPTAPSQ INDTMGEARA
GAGGLGLMVL PPPTPSIDAD EEFVFADPLP PPLQFANGKN ERMKEFSQHY QVQSHYSASA
PQPVPPSVPS PKLSNAPQST SQGGDSAASS LTSYDSEPIS LSHPYYSSSN EPSVNWQDAV
VDSGIEELDS HSSSDHHLEM LGLSGLRGDR GGVGVDGGKG GQHQDPCTTY LGGQAFEVHS
TKLANPVFPK MTHYKEVEGR GPTIALRRQS SINPQGVVQS GGMVLEGPSI INELSSKLQH
MSSMRSMDDW SHAPKSPSPQ MPTSPVHSHP PHSPTYCPYP TSPKHRSKMR RQTFDFQCSP
TKEMRSSVSR RRAPSPLIYN TEQPNPTPPR PSPNPLLFSP SSPMHLPPSP SCLNYPQISP
PPPAKPFAIK PLPYWTKYDV ADWLAYLNLG EHTERFIDNE IDGSHLPSLT KDDFLDLGVT
RVGHRMNIER ALKKLTDR
//
