ID A0A3Q3AMI1_KRYMA Unreviewed; 426 AA.
AC A0A3Q3AMI1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Paired box protein Pax-8 {ECO:0000256|ARBA:ARBA00039822};
GN Name=PAX8 {ECO:0000313|Ensembl:ENSKMAP00000012649.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000012649.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000012649.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3Q3AMI1; -.
DR Ensembl; ENSKMAT00000012834.1; ENSKMAP00000012649.1; ENSKMAG00000009439.1.
DR GeneTree; ENSGT00940000161868; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00131; PAX; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR022130; Pax2_C.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PAIRED BOX PROTEIN PAX-6-RELATED-RELATED; 1.
DR PANTHER; PTHR45636:SF6; PAIRED BOX PROTEIN PAX-8; 1.
DR Pfam; PF00292; PAX; 1.
DR Pfam; PF12403; Pax2_C; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 4: Predicted;
KW Paired box {ECO:0000256|ARBA:ARBA00022724};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 52..178
FT /note="Paired"
FT /evidence="ECO:0000259|PROSITE:PS51057"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 426 AA; 45756 MW; 37A774EFB11C0054 CRC64;
MFPVVLQSGS GGALGGAHSC QTRRSDSTYR GTAAEEESDT FGWWNKEQTL RDMSSNSGRG
GMFVNGRPLP EVIRQRIVDM AHQGVRPCDI SRQLRVSHGC VSKILGRYYE TGSIKPGVIG
GSKPKVATPK VVEKIAEYKR QNPTMFAWEI RDRLLAEGVC DSDTVPSVSS INRIIRTKVQ
QPFNLPLDGK GLSPGQTLIP SSAVTPPESP QSDSLGSTYS INGLLGIPQP NTDGKRSHDD
SDQESCRHSV DSQGSGGVPR KQMRVDHFAV ATQHLDCGFD RHHYPPESFS SASSSKTEQT
LYPLSLINGS LDEAKSSLSA SGSVIGRNLS AHQSFSVVTG RDMVSSTLPG YPPHIPSPAQ
TGYSSSAITG MVAAGADYSG QSYSHSPYTS YSEAWRFTNP SILGSPYYYS SASRTGPPSA
AAYDHL
//
