ID A0A3Q3ANM4_KRYMA Unreviewed; 1527 AA.
AC A0A3Q3ANM4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=MAM and LDL receptor class A domain containing 1 {ECO:0000313|Ensembl:ENSKMAP00000018001.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000018001.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000018001.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSKMAT00000018252.1; ENSKMAP00000018001.1; ENSKMAG00000013362.1.
DR GeneTree; ENSGT00940000165597; -.
DR OMA; YMGDVVI; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00112; LDLa; 9.
DR CDD; cd06263; MAM; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 9.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR23282; APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR; 1.
DR PANTHER; PTHR23282:SF142; MAM AND LDL-RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00629; MAM; 6.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 10.
DR SMART; SM00137; MAM; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR SUPFAM; SSF57424; LDL receptor-like module; 9.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01209; LDLRA_1; 5.
DR PROSITE; PS50068; LDLRA_2; 9.
DR PROSITE; PS50060; MAM_2; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1476..1500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 111..273
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 319..492
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 544..707
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 755..917
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 951..1106
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1155..1319
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1418..1457
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 7..19
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 14..32
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 76..88
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 83..101
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 95..110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 301..316
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 527..542
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 715..727
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 722..740
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 915..927
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 922..940
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 934..949
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1121..1139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1133..1148
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1349..1364
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1378..1390
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1385..1403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1397..1412
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1447..1456
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1527 AA; 168730 MW; 9A9C054DD816CEB4 CRC64;
RVFVTTCSDH EFTCSQGLCV DQDSVCDFTD DCGDGSDEEN QVVIRGELSA NSEAAEVLAI
DDLSFAEGGA PPPPSCPPSW FHCGEGECVE DSKVCDFTPH CSNGEDEASC SECSFESSSC
GWYELTLGDG FDWIRGSSVE IPPDYYNHPA LPDHSTNSTE HFMFILKNSS SLHPKAILRG
PWFQQSASGC TLTFHYNSGI SVGAADMYLR LKGVQNNTAI WTTLYDQGRR WNQVTVQLGR
ITQPFQIALA KISLGVFDGI SAFDDVSFRN CSMPLAVAAC PTDTHFHCVH TKACVEHLQL
CDLVDDCGDG SDEEGCPELQ CDFEDGLCNW KQETRGGDEF NWTRISGPTP TLNTGPWRDH
TLGTWYGHYL YIESSSPQEF KDTAVLLSPV FKPTYQPGKD PAFSHRSHCV FRFYYCMFGS
HVFSLAVYLR TTSTGRGPML WAKYGNQGNL WHRKTLYLHS AQPFQILIEG TVGDDFKGDI
AIDDLSFLDC ETLDVTTPAP TVLPHSCPEG QFVCGAYGEC VDLSQVCDFK RDCSDGSDET
NCKGRCDFEG GDTCGWTIFN PSLVLNHAFV WATDQGETIH DGEQNHRPAN DHTEGWYMCA
DSSNGGYGQI SDLQTPVISL TGPRCTLVFW YHMSGFTVGS LQVLLRHKNV TYVVWSQTGN
QSNKWRQGEV FLGLTNNIQQ VVFRAKRGIS YMGDVVIDDV SFQDCSPLLP SDKPCTSEQY
ACANGHCIPQ DSLCDFINHC GDNSDEDPYI CGFSGRCDFE FDLCSWRQCQ QDDFDWLIKA
GSTPTIGTGP SSDHTLRDPT GHYLYLESSF PQAVGDAARV IGPLLSRRSS QCKMRFYFHM
SGDGIGTLNV FTKTDGHDHL LLNLTGDQGN YWQMREIQLS SSRDFKVVFE GKVGRSEKGD
ICLDDITFSP GCLFCPPGSM LCEKGSCFTP EQSCDFTDDC GDGTDEKDCG TSCSFENGRC
GWKTSLADNF DWALGTGSVQ SIRPPYDHTL MNENHFVYLE ATPVGLKGDK AHVRSSVWKE
SSALCKLSFW YYISHKATGT IRLLIKTENN LMEMWNKTGH QGNKWNRAEV PLRKLRNFEV
IFEGIRSFDV SGGAAVDDLE FIDCAPAAEP GSCPAVTDFV CHSGGCIESH LVCDNKADCA
DESDEMDCHI FDSPGACDFN MEEEGWEDSC QLFQDADDDF DWRIGHKTET PGAGPHTDHS
PGEGNFLYIH SAPQREGDVA KVTTRNPFPA SIGLCHLRFW FFMHGSDRMG TLKVYTVGPS
GAHLLMWAAT GNHGNQWTYA NVILSNTAPF RVTFQAEVGG DVWTDIALDD ISYTAECTVG
PVTPQPLTCG GDQFQCLYSF QCIPKSWWCD DEPDCTDYSD EEHCPTAVPG TLPPQGLCPA
RYYQCSDHQC IPSVLRCDGV LDCPDGEDEH SCELVCESPS GCIPPLKRCD ESTDCLPFHT
DESSCHCLPG WTGNRCHVKE KPSLPTSSPT PEDTRLSVYA GIGIGLLLLA AGVTVCFLAL
CRKKSNFKSD PMKYGVMDDP DSDWGAE
//
