ID A0A3Q3ANP3_KRYMA Unreviewed; 495 AA.
AC A0A3Q3ANP3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Glycine receptor beta {ECO:0000313|Ensembl:ENSKMAP00000013074.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000013074.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000013074.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU000687}.
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DR RefSeq; XP_017273019.1; XM_017417530.1.
DR AlphaFoldDB; A0A3Q3ANP3; -.
DR STRING; 37003.ENSKMAP00000013074; -.
DR Ensembl; ENSKMAT00000013274.1; ENSKMAP00000013074.1; ENSKMAG00000009806.1.
DR GeneID; 108236681; -.
DR KEGG; kmr:108236681; -.
DR CTD; 445193; -.
DR GeneTree; ENSGT00940000156344; -.
DR OMA; KFFWGIL; -.
DR OrthoDB; 4265336at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:InterPro.
DR GO; GO:0016934; F:extracellularly glycine-gated chloride channel activity; IEA:Ensembl.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR CDD; cd19061; LGIC_TM_GlyR_beta; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR008060; Glycine_rcpt_B.
DR InterPro; IPR047029; GlyR_beta_TM.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR NCBIfam; TIGR00860; LIC; 1.
DR PANTHER; PTHR18945:SF29; GLYCINE RECEPTOR SUBUNIT BETA; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR01677; GLYRBETA.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Signal {ECO:0000256|RuleBase:RU000687};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687}; Transport {ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 23..495
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5022251785"
FT TRANSMEM 265..286
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 328..349
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 473..493
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 57..264
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 272..491
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT REGION 445..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 55787 MW; 20DADE58E38A7E39 CRC64;
MDRKKFAIFI LLLFLCLEGG SAKEKGAKKG KKKGKQVYCP SQLSSEDLAR VPANSTSNIL
NRLLISYDPR IRPNFKGIPV EDRVNIFINS FGSIQETTMD YRVNIFLRQR WNDPRLKLPQ
DFKSDSLTVD PKMFKCLWKP DLFFANEKSA NFHDVTQENI LLFIFRNGDV LISMRLSVTL
SCPLDLTLFP MDTQRCKMQL ESFGYTTDDL QFMWQTGDPV QMDAIALPQF DIRQEDIDYG
NCTKFYEGTG YYTCVEVIFT LRRQVGFYMM GVYAPTLLIV VLSWLSFWIN PDASAARVPL
GILSVLSLSS ECTSLASELP KVSYVKAIDI WLIACLLFGF ASLVEYAVVQ VMLNSPKHIE
AEKAKIASKE KAAGKSPAAR NNTINGTGGT PLHVSTLHVG ETRCKKVCTS KSDLRTNDFS
IVGSLPRDFE LSNFDCYGKP IETGSGFGKS QAKNKKPPPP KPVIPSAAKR VDLYSRALFP
FSFLFFNVIY WSIYL
//
