ID   A0A3Q3APQ6_KRYMA        Unreviewed;       439 AA.
AC   A0A3Q3APQ6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Equilibrative nucleoside transporter 2-like {ECO:0000313|Ensembl:ENSKMAP00000018853.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000018853.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000018853.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004554}. Lateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC       {ECO:0000256|ARBA:ARBA00007965}.
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DR   AlphaFoldDB; A0A3Q3APQ6; -.
DR   Ensembl; ENSKMAT00000019114.1; ENSKMAP00000018853.1; ENSKMAG00000014022.1.
DR   GeneTree; ENSGT00950000182898; -.
DR   OMA; RDCETAG; -.
DR   OrthoDB; 517168at2759; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015213; F:uridine transmembrane transporter activity; IEA:UniProt.
DR   InterPro; IPR034764; ENT1/ENT2.
DR   InterPro; IPR002259; Eqnu_transpt.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   NCBIfam; TIGR00939; 2a57; 1.
DR   PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR   PANTHER; PTHR10332:SF8; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2; 1.
DR   Pfam; PF01733; Nucleoside_tran; 1.
DR   PIRSF; PIRSF016379; ENT; 1.
DR   PRINTS; PR01130; DERENTRNSPRT.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        128..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        189..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        273..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        344..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        378..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        413..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   439 AA;  48725 MW;  83A3E37A3802F7EE CRC64;
     MWSEKKPSPP SDRGQAVAVI IFVLGVGTLL PWNFFITASQ YFNDRLRESH SLTNSSADAS
     LKDYNYDSWM ALLSQLPLLL FTLLNSFLYQ RVKERLRVAF SLMVIFLLFS LTAALVKVDM
     DPDTFFSVTM ATIWFINTFG AVLQGSLFGV VGLFPPRYST LFMSGQGLAG IFAAVAMLCS
     ILSKPDRNSA ALGYFITPCV ATLGTLLCYL LLPHLEFAHF YLKRNQPDKV ELDSTDKKAL
     NSNMKDLEAN GKTYVEPDDG QERSSVLAVF KKIWLMALCV TCVFAVTLSV FPVITVRVQT
     VYTENSDWEK VFTCVCCFIV FNVMDLAGRS APSLFQWPSK GSRLFPVAVL SRLVFIPLIM
     MCNIQGSKLK VLFAHDCAFV SIMALFSFSN GYLASLCMAY APQLVRCRDC ETAGSLMTFF
     LVLGLALGAS LSFLLGKLV
//