ID A0A3Q3ARQ4_KRYMA Unreviewed; 1346 AA.
AC A0A3Q3ARQ4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Rho guanine nucleotide exchange factor 11 {ECO:0000313|Ensembl:ENSKMAP00000019176.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000019176.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000019176.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 37003.ENSKMAP00000019176; -.
DR Ensembl; ENSKMAT00000019439.1; ENSKMAP00000019176.1; ENSKMAG00000014194.1.
DR GeneTree; ENSGT00940000158350; -.
DR OMA; FICGERQ; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 11; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800}.
FT DOMAIN 48..112
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 683..869
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1095..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1199..1248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1315..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..161
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1220..1242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1346 AA; 148884 MW; F554621CA08695F6 CRC64;
MSLRQPTSTL DRLSSLTTGD SDRRSSASQQ KEPTADVFAE GAGLVQRCVV VQKDQLGFGF
TVCGERVKLV QNVRPGGAAV KAGVHEGDRI IKVNGLLVSS MSHQEVVKLI KSGPYVALTL
QGTPPSVPLE PLPSNLTPNQ RTSMSGDTPP PPPPPLPSGP SSTPSQRITG PKPLQDPVVQ
KHASQILRKM LEQEEAELQD LLDEQLRNPS PSLEERIESA KRRAHQVRVK IQQDLVMTFF
CLCLCVSQGG RAQIISPEEE EEEEGYALNE MDGPFQDIEL LKSRPAHMMV FMRYVFSQLL
DPNPLLFYLS VEAYLGSSPK DARGLAPQIC SHFLDPDAPL KIKVREEYLT DIESRLHAQE
DIRGPLSELQ QQVLPDIQEL IQDYRNKQMM GLGSLFGEGD LHLLDGDPVK EKQVVDRQVT
ALWEILSKHE EDRSSPLASA VLLYLRHSGI KLRDSKVFPS LSTEKEKWLA FLKTKKLSSN
KEKKDGEDKK RNPILKYIGK PRTTSQSMRP GSVRNIIQQF ENHTDAPGEE GGDAADPQRL
SSSSLGEEGK EGMDSPTVSV RLARSESLKA QGEGRRRGAA SGGDSVPRSR SDVDMEDCGE
EQDQQGLRPL QHSASSSASS NSARSLENPT PPYTPRSRRR SVDSPLALLP DAAAVEEEVC
DGQNWQETVP PHLLTTLSPK EVDRQAVIYE LFTTEVSHLR TLRVLDKVFF QKLRSVLNSE
ELACIFPNLP QVYELHASLC EAMKKRRETP VVQDIGDVMV ARFEGAAGSE FQEQASLLCC
HQSPALELIK NKKRKDPRFA QMIQECEASP QCRRLQLKDL LVSEMQRLTK YPLLLDSIIK
HTEAGSKDLP SLQHAQTCCR GILQAVNEDV RETEHSRRLV QYQRRLDAAP QFKHLDLTTK
RMIHEGPLIW KISKDKQIEI QALLVSDYLL LLHKSPDDRL QLRYPSRLFG GGGGGVGSGD
SKTSFSPLVK LDSLLVRPVA TDNKALYIIS TTESQIYELV MGSSSERNTW KDLLEKAITA
AGVVFDLPAN SMVEQSDSME TQSSNEDDNI SDNTPTELSG AGNCDEGQEG GVAEAALQDV
ETLRHLILQD LDEDGWSHNS DDTPTNKMTN GGSSLTERRR PESLETVLNL STEEEAGPDV
CLPTDIRQPS LKVVRKAVVA GPPPSSVPDG ITDDVSLLSN QSSKSRGNTF YLVMPSEQGE
SNIDDLSDPP TPTASHFPQP EEEVMSQQTQ PKAGVPEFSQ SETMQLEEEK EEAVPSQAGT
QSHIIRNVDE IFLTFEGLMN KLHKLKEIET AHHKLLETLR DPSFSLESED QPCCSATVSR
TPSMDRSSVE GKEGIPAEPK ILSTGF
//
