ID A0A3Q3ARV1_KRYMA Unreviewed; 1000 AA.
AC A0A3Q3ARV1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Protocadherin alpha-C2-like {ECO:0000313|Ensembl:ENSKMAP00000014174.1};
GN Name=PCDHAC2 {ECO:0000313|Ensembl:ENSKMAP00000014174.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000014174.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000014174.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain. {ECO:0000256|ARBA:ARBA00003436}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_017268055.1; XM_017412566.1.
DR AlphaFoldDB; A0A3Q3ARV1; -.
DR Ensembl; ENSKMAT00000014385.1; ENSKMAP00000014174.1; ENSKMAG00000010638.1.
DR GeneID; 108233861; -.
DR KEGG; kmr:108233861; -.
DR GeneTree; ENSGT00940000160554; -.
DR OMA; RVATIYI; -.
DR OrthoDB; 4259465at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF119; PROTOCADHERIN ALPHA-C2; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 19..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..138
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 139..247
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 248..355
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 356..459
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 460..569
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 582..680
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 736..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..974
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1000 AA; 108489 MW; 38E81F49020D53D1 CRC64;
MAVTGKICNR TGSSINVPFY FVLFSLFCGL ACGQLRYSIT EELENGALVG DLAHDLGLDI
RKLASRRIKI TSSSSGKRYL IVNPKNGKLL VNDRIDREAL CDLSSTCLIN LEVLVENPTE
VHHVEVEIVD ANDNAPQFPR DEYQLEIIES ALPGSRYPIE NALDPDVGSN SVRMYQLSTN
ENFALVSNKP SLNTKHIELV LKKPLDREQT PYHQLILSAV DGGIPDKTGT AKINIRVLDS
NDNIPQFDSS VYKVKLLENS PKDTLVIKLN ATDLDEGTNA EVYYSFSSYT PERVRQMFSM
DTNTGEIRVR SNVDYEETVS YEMYIQAMDK GPGAVAAHCK VVVEVVDVND NVPQIVLSSL
SSPVREDARA DTVVALISVT DRDSGANKQV SLEIPAGLPF KIKSFRNYYT LVTSAFLDRE
TTDAYNVTLS ATDGGNPPLS SQKTIQVDVA DVNDNPPRFE QTSYTVYVAE NNAPRASLCT
VKAQDADIKE NARITYTVLN DNNHGIPVTS YVSVKADTGE AYALRAFDYE SLREFHFQVK
AQDGGIPPLS RVATVYIYIM DQNDHAPVIV SPAGNGTRSL ETVQKNADSG ALVTKVVAYD
ADAGPNAWMA YVLETATDLD LFKVHEHTGE IRTTRRILED NSTSFALTVV VKDHGQPALS
STATINVAVM EIPPKVAPDT KKVSRPHNTL FLSNVTLYLI VALSATTFVF LVTVVVLAIV
RCHAYCSQPG SCCGSQKPPP DGGSSSVSAG GGGSGGAAGQ PNNNVVLRRD LKVEPHYIEV
RGNGSLTKTY CYKTCLTATS GSDTFMFYNT GRPISGTWGS GADRFFTSGS GFVRRLSMPD
ASLQICPEPK APNADWRYSA SLRAGVQGAV HMEESSVVQG AQGMLVQNWP TVSSAADGEG
GGELSPPVGA GVNSNSWHFR YGAGQGYMPP QPLKPGEIPP EAFIIPGSPA IISIRHDSGP
VDDKGDFISF GKKEEAKKKK KKKKDKKDKK EKGKDDGGDD
//
