ID A0A3Q3AT52_KRYMA Unreviewed; 2468 AA.
AC A0A3Q3AT52;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Myosin XVIIIA {ECO:0000313|Ensembl:ENSKMAP00000019620.1};
GN Name=MYO18A {ECO:0000313|Ensembl:ENSKMAP00000019620.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000019620.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000019620.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_017287670.1; XM_017432181.1.
DR STRING; 37003.ENSKMAP00000019620; -.
DR Ensembl; ENSKMAT00000019886.1; ENSKMAP00000019620.1; ENSKMAG00000014471.1.
DR GeneTree; ENSGT00940000155768; -.
DR OrthoDB; 3687088at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01386; MYSc_Myo18; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR036064; MYSc_Myo18.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF13; UNCONVENTIONAL MYOSIN-XVIIIA; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR Pfam; PF00595; PDZ; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
FT DOMAIN 222..313
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 407..1171
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1398..1420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1433..1460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1842..1863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2166..2199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2225..2261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2292..2452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1235..1332
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1398..1413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2175..2199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2225..2255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2292..2313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2314..2343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2344..2359
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2367..2383
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2384..2423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 500..507
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2468 AA; 279218 MW; 5FA5F7F2CAB1773A CRC64;
MFNLMKKDKE KDGAKKEKKK ERMSAAELRS LEEMSMRRGF FNLKRESKRS KVEISGPIPI
KVANSTELSL TDLESDGLSN RSSVILDDQL STASSTDDLK GEGGGGQEGH RSSVRDRVAH
FGSIAKQNSS QVGQMMKRFS FSQRSKEESP SESSTPSGQN SAAPSPQVEN KVFNILRKQS
QKLQPGAADT KKVCIPQLVD KVFPAQLQLP AVVAPSTPET RELELQRRNT GDFGFSLRRT
TMLDRSPDGG VYRRVVHFAE PGAGTKDLAL GLVPGDRLVE INGRNVENKS RDEIVEMIRQ
SGDTVRLKVQ PILELSELSR CWLRNSEGLR RGVRHVKTEE QIAAEQAWYG SEKVWLVHKD
GFSLATVVKT EAGSLPEGKV KIKLEHDGTL LDVDEDDIEK ANPPSYDRLE DLASLLYLNE
SSVMHCLRQR YGGNLIHSFA GPNMVVINPL STPSMYSEKV MHMFKGCRRE DTAPHIYAVA
QSAYRNLLTT RQDQSIVLLG KSGSGKTTNC QHLVQYLVSI AGSTGKIFSA EKWQAVYTIL
EAFGSSSTAM NTNASRFSHV VSLDFDQAGQ VASASIQTML LEKLRVSRRP EAESTFNVFY
YMMAGADSSL RTELHLNQLA ENSAFGIYPH SKPEDKQRAS QQFTKLQAAM KVLGISGEEQ
KALWLILGAI YHLGAAGGTK DGDEVGRRQF ARHEWAQKAA YLLGCTLEEL SSLIFKHQAR
GLQPTTSFRG GADDAGQGDS SGSKFTALEC LEAMASGLYS ELFTVVISLI NRALKSSQHS
LCSLLIVDTP GFQNPRLAQQ QRGATFEELC HNYTQERLQT LFHERTFVRE LERYKEENIE
LVLDDIESST SLSVAVIDQA SAQALVRALA RTEEARGLLW LMEEEAVQPG GSEETMLERL
FSYYSSSQGE NKGASLLLRG EKPHLFLLGH SHGADWVEYN VQGWLSHAKN NPAAQNAAAL
LQDSQKKNIS GLFLGRSSGA TVLSGSIAGL EGSSQLALRR ATSMRKTFTT GVAAVKKKSL
CIQVKLQVDA LIDMVRRSKV HFVHCLLPKA EAVGGADLRV THGESPDAGL MNLDLHLLRA
QLRGSKLLDA LRIYRQGYPD HMVFSEFRRR FDVLAPHLTK KHGRNYIVTD EKRAVEELLE
SLELEKSNYH MGLSRVFFRA GTLSRLEEQR DVQTRRNISL FQSACRGYLA RQAFKKRKIQ
DLAIRCIQKN IKKNRGVKDW PWWKLFTTVR PLIEVQLTEE QIRGKDEEIQ QLKQKLEKVE
KERNELRLNS DRLESRITEL SSELTDERNT GESASQLLEA ETAERLRLEK DLKELQSKFD
SMKKQTESME MEVMEARLIR ASELNGEMDD DDTGGEWRLK YERAIREIEF TKKRLQQEFD
DKLEVEQQNK RQLERRISDL QADNEESQRN IQQLKKKTQR LTSELQDTKL HLEGQQSRNH
DLEKKQRKFD GELSGAQDEV QRERSLREKL AREKDMLSAE VFSVRQQLED KDIELCAVNL
KLEQLEAELQ DLNSQESKDE ASLAKMKKQL RDMEAKVKDQ EEELDEQAGT IQMLEQAKLR
LEMEMERLRQ SHSKEIESKD DEVEEIRQSC SKKLKQMEVQ LEEDYDEKQK VLKEKRELES
KLLSAQTQER SADIETEKRL RKDLKRTKAL LTDAQIMLDH IKNNAPSKRE IAQLKNQLEE
SEFTCAAAVK ARKAMEVEID DLHVQMEDTS KTKQALEEQL SRLQREKNDL QSRMEEDQED
LNELMKKHKA AVAQSAQNLA QISDLQSQLE EALKDKQEVQ EKIQVLQSQL DFQEQSMVEK
SLVSRQEAKI RELETKLEFE KTQVKRLENL VARLKENLEK LTEERDQRFS SENREKEQNK
RLQRQIRDVK EEMAELAKKE AEASRKKHEL EMDIESLEAA NQSLQADLKL AFKRIGDLQA
AIEDEMESDD NEDLINSLQD MVTKYQKRKN RTQGLSDSDS EVEDRVDGVK SWLSKSKCSM
KNLSDDGSLK SSRYAVNLDA KEGKEWKDWK EANKEDKEVE TNRPVSVMSS LSYRKRSNLD
SVGSKDVLLS ALKENADSED VLTFQKAKSK TSDPHDDAYS VSCRKTSQLQ EVINGRESVI
SQAYSEANSR ARRGIDSRWS QVDKESSFSR PSRNLSLISE NKPGTSFCLS SPPGFHRSIS
HLEEGRGDRL RYGSSPSSPC FSRRSRSRSP GNVSQADSHM LLARSSRLSE FDIDMDDSRS
VAFTERSAYS PHSSTGRSVS MPPPQARSTF DNYSVDDSDI KPVSHRSYLD PDLEKAINEV
LSFKPITFKR RSLEDSEDEI SKNNKDEGKS LKNGDGTRPT SSVRHSESAV DCRSQSRSTS
SCSKRSSKSK KKKRSHSSES HNSRGKTRHR SSSKRRSKRS KKKNQTSSSS SSSSSSDSES
DSGSSSDAST ISYRSSSSVK KAPAKTVSDP DSEEGTTEGP PLNKMDEKKR KKKVDSLVMK
YLYRPDSD
//