ID A0A3Q3ATA7_KRYMA Unreviewed; 1026 AA.
AC A0A3Q3ATA7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Zinc finger E-box binding homeobox 2a {ECO:0000313|Ensembl:ENSKMAP00000019771.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000019771.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000019771.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger
CC family. {ECO:0000256|ARBA:ARBA00009867}.
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DR AlphaFoldDB; A0A3Q3ATA7; -.
DR Ensembl; ENSKMAT00000020036.1; ENSKMAP00000019771.1; ENSKMAG00000014703.1.
DR GeneTree; ENSGT00950000183208; -.
DR OMA; MAQSPRW; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:UniProt.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR008598; Di19_Zn-bd.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24391; HISTONE H4 TRANSCRIPTION FACTOR-RELATED; 1.
DR PANTHER; PTHR24391:SF11; ZINC FINGER E-BOX-BINDING HOMEOBOX 2; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF05605; zf-Di19; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 68..96
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 98..120
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 139..166
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 475..535
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 810..837
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 838..865
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 866..894
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DNA_BIND 477..536
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 202..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..979
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1026 AA; 115020 MW; 381AD512D73BFFDE CRC64;
SNQNLDDYLL KRKLEDGIGH PATFVEYLQR SDTAIIYPEA PEEATRLSTP EATGQDEGDA
TDDFAQLLTC PYCERGYKRL TSLKEHIRYR HEKMEESFTC PLCTDAFTQR AQLERHMTSH
KPVTDQPPLL SEGAANRKFK CSECGKAFKY KHHLKEHLRI HSGEKPYECS NCKKRFSHSG
SYSSHISSKK CIGLIALNGR VRNVNKPGSS PNSTTSSPGS PTLAPLRHKL ENERPLGPSH
QPGLLDIKAE PMDFNEYLLL MASQHGFGGP AIYLNGRSRS PLGIRSSSQT TLQNLGGMGL
DLSLLGYTGP LGNSLSEIQK VLQIVDNTVY RQRIDGNLEE ISKLRAYMKE LGAQMEPQAG
FHMMCQSSPT KNIIDYTLEK VNDAKNLINE SKMQMDVKKE KSVDFISEEK SPDGQNQFLP
FSCQYCKETF PGPIPLHQHE RYLCRMNEEI KAVLQPTESS PASCRGLMVD ELSSTEKTTS
PTSLFKDHIS VLNAYFSMNT EPNSEELLKI SLAVGLPQEF VKEWFAKSKS QNHMDSLRTK
LPPIDHCGLD HSLSQSPVSL PAINLHDGIP NNNATHGLTT TNQFAANKQT TGDKSLDPTD
SLKISTLSPL NLSSTLSKNS QSTSYTQNSL EGHGDTPLDL SLPKHMAQRR LRPNGFITEH
NGELSGHQQE FEPLELVNIK KEVLGSDVGE NSIHRLGKST SPIFGINPFA TGPVYTSLPP
HRAFPPPTFL NQAAIPGLRP YQGLEPMSFL PHMPYTYSTG ATFAEMQQRR KYERKASFQG
GLLEGTMDSL SDSDSLLSRK KIKKTESGTY ACDLCDKTFQ KTSSLLRHKY EHTGKRPHQC
QICKKAFKHK HHLIEHSRLH SGEKPYQCDK CGKRFSHSGS YSQHMNHRYS YCKREAEERE
AAHREARDQG GLEPTQLLMR SAYLQGLGPL GYSDPEDQPE DGSGTMLRGR REGGGQEKMK
VDSKMFEEVT DRQEASFRKT EEEEEEEVEE SDSRSQSVMD EGQDFTQLLD QCSGEEKTDG
RLDLED
//
