ID A0A3Q3AU17_KRYMA Unreviewed; 906 AA.
AC A0A3Q3AU17;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Semaphorin 4D {ECO:0000313|Ensembl:ENSKMAP00000020046.1};
GN Name=SEMA4D {ECO:0000313|Ensembl:ENSKMAP00000020046.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000020046.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000020046.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR RefSeq; XP_017263336.1; XM_017407847.1.
DR RefSeq; XP_017263337.1; XM_017407848.1.
DR RefSeq; XP_017263338.1; XM_017407849.1.
DR RefSeq; XP_017263339.1; XM_017407850.1.
DR STRING; 37003.ENSKMAP00000020066; -.
DR Ensembl; ENSKMAT00000020312.1; ENSKMAP00000020046.1; ENSKMAG00000014901.1.
DR Ensembl; ENSKMAT00000020333.1; ENSKMAP00000020066.1; ENSKMAG00000014901.1.
DR GeneTree; ENSGT00940000159594; -.
DR OMA; PCLKFRS; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF18; SEMAPHORIN-4D; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 770..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..521
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 576..645
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 671..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 906 AA; 101338 MW; 97539D02193A1464 CRC64;
MNEYLLSDAM TDKGNFTVPK LTDSNMGVGV LGVFLGLLLE VSTHGPHSVP RTSWKHQDVD
LLEFSEPEIF NYTTLLLSEE RDALYVGARE AIFELSKKNV TVKNHKVQWT VTDDHMNMCT
LKGKSKERDC LNYIRVLQVV DDERLYVCGT HAFQPQCNYL NLRDFSLEGQ TEDGRGKCSF
DPSQSFTTVM VDGELYSGTS YNFLGSEPII SRYSPSHSLL RTEYSTSWLN EPSFVFADVI
REGKNREVGE GDKIYYFFTE VSVEYEFFGK LLIPRVARVC KGDLGGQRTL QKKWTSFLKA
KLVCSMPELN FVFNVVHDIF ILKGKDWRDT IFYGVFTSQW GNVGLSAVCA YNMTAVEEIF
SKGKYMQKAT VEQSHTKWVR YNGITPSPRP GACINNEMRR QNINSSLNLP DKTLQFVKDH
PLLEDPILPI GNRPRLITKD VNYTQLVVEK VQALDGNIYD VIFTGTDKGV LHKSVVFQEE
VHIVEEIQLL KNSEPIKNLL LSSQTRSVYA GSDSGVVQTP TAFCRKYLSC DDCVLARDPY
CAWDPNTAAC VSIFDTPRQS LRKLIQSLNG DANKCPPVPQ RDYQSVLVKP GSSAELPCLV
NSNLAHVMWK SNGSVLSEAS RFHFIAESGL LIYSVAPEDQ GYYECWSVEW APAARKNFSR
LLAGYMVKLD LPPRPPPQST HATTTLSSEE KSNVHAAEGN VETQRDSLTS TSFTATVLLT
SPPQTDSSLT PPPSSTIKVQ PKRNLPPNSA ASHPASLEPE AEYLQHNNSV ALLFLFLLFF
LLFLAAMVYN CYMQYLPAPC LRLRTALLGT HKCSHQPEYR ACEAGLMETS ATDKINMTEQ
PTQNGSQAAQ NLQALRDTGY ETEPECGNGR LPSHSFGSNS PSQEKPFDVD CDSQSIQFAD
ADEPCS
//
