ID A0A3Q3AU35_KRYMA Unreviewed; 2096 AA.
AC A0A3Q3AU35;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Dedicator of cytokinesis 7 {ECO:0000313|Ensembl:ENSKMAP00000014999.1};
GN Name=DOCK7 {ECO:0000313|Ensembl:ENSKMAP00000014999.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000014999.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000014999.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 37003.ENSKMAP00000014999; -.
DR Ensembl; ENSKMAT00000015216.1; ENSKMAP00000014999.1; ENSKMAG00000011135.1.
DR GeneTree; ENSGT00940000155661; -.
DR OMA; FPHQFND; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF78; DEDICATOR OF CYTOKINESIS PROTEIN 7; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800}.
FT DOMAIN 558..724
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1642..2070
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 135..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1228..1252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2096 AA; 238032 MW; 8F1809A936ADF495 CRC64;
MAERRAFAQK ISRTVAAEVR KQIAGQYGGS PQLFKNLNVG TTSSNTVPLT EAVEPVDFEE
YLITHPPIVE SGPLRDLIEF PPDDIEVIYT PRECRTVVQA VPEEGDTDPH VRDCVRSYTE
DWAVVNRKYH KLGTGFNPNT LDKQKERQKG LPKQVFEADE MPDSSSYQDD QDDLKRRSMS
IDDTPRGSWA CSIFDLKNSL PDALLPHLLD RAPNEEIDRH NEEQRLSNRH RELFALHPAL
DEEEPIERHC VPEVPKEHFG QRLLVKCLSL KFEIEIEPIF ASLALYDVKE KKKISENFFF
DLNSEQMKAM LRPHIQTAAI STLARSAIFS ITYPSQDIFL VIKLEKVLQQ GDIGECAEPY
MVFKESDAAK NKEKLEKLRG QSEQFCQRLG RYRMPFAWTA IHLMNIVNSA GSLERDTELE
MSLSERKGSW SERRNSSIMG RRSLERTTSG DEACSLTGFR PATLTITNFF KQEGDRLSDE
DLYKFLADMR RPSSVLRRLR PITAQLKLDI SPAPENPHYC LTPDLLQVKP YPDSRVRPTR
EILEFPARDV YVPNTTYRNL LYVNPQSLNF ANRQGSARNI TVKVQFMNGE DPNNAMQVIF
GKSSCADFYK EAYTAVVYHN RSPDFHDEIK IKLPASLSDH HHILFTFYHV SCQQKQNTPL
ETPVGYTWIP MLQNGRLRTG HFCLPVSLEK PPQSYSVLSP DVPLPGMKWV DNHRGVFNVE
LVAVSTIHTQ DQYLDKFFAL VHALDEHVFP VRIGDMRIME NNLEAELKAS IAALTSAQLE
PVVRFLHLLL DKLVLLVVRP PVIAGQIVNL GQASFEVMAS VVNRLHKYLD TSQDMHGRNS
LLSSYIHYIF RLPSTDPNSP SPGPGGLGGS VHYATMARSA VRPASLNLSR SRSLSNSNPD
ISGTPTSPDD EVRSIIGSKA MERCGNRMSS HTESASFLQT LTGRLPTKKL FHEELALQWV
VSSGSVREGA LQQAWFFFEL MVKSIIHHLY FTDRLESPRK NRFPERFMDD ITALVSTIAG
DIVSRVQKDL ELVERLNTSL AFFLNDLLSV MDRGFVFMLI RTYWKQVSTK LYALQNPTME
SLRLDFLRIV CSHEHYVTLN LPCSLLTPPA SPSPSVSSAT SQSSGFSTHV QDQKIANMFE
LSVPFREQHY LAGLVLSELS VILDPDNEGM FGLHKKVVSV VHNLLSSHDS DPRYADPEVK
ARVAMLYLPL IGIVMETLPQ LHDFTESHNQ WGRPGGPQGA AVGSGGEEAE GEGNSMISQT
VAMAIAGTST ASPMSRPSSF LLNSQASRQH GSFSAESSRS LLICLLWVLK NADELVLQKW
FTDLSVSQLN RLLDLLYLCV SCFEYKGKKA FERMNSLTFK KSKDMKAKLE EAILGSIGAR
QEMVRRSRGQ LERSPSGSAF GSQENLRWRK DMTHWRQNTE RMDKTRAELE HEALIDGNLA
TEANLIILDT LEIIVQTVSV TESKESILGG VLKVLLHSMA CNQSALYLQH CFATQRALVS
KFPELLFEEE TEQCADLCLR LLRSCSSSIS TIRSHASASL YLLMRQNFEI GNNFARVKMQ
VTMSLSSLVG TSQNFNEEFL RRSLKTILTY AEEDLELRET TFPDQVQDLV FNLHMILSDT
VKMKEHQEDP EMLVDLMYRI AKGYQTSPDL RLTWLQNMAG KHSERNNHAE AAQCLVHSAA
LVAEYLSMLE DRKYLPVGCV TFQNISSNVL EESAVSDDVV SPDEEGICSG KYFTEIGLVG
LLEQAAASFS MAGMYEAVNE VYKVLIPIHE ANRDAKKLAT IHGKLQEAFS KIVHQVSTWM
FGTYFRVGFY GSKFGDLEEQ EFVYKEPAIT KLAEISHRLE SFYGERFGEE QVEVIKDSNP
VDKCKLDPNK AFIQITYVEP YFDTYEMKDR ITYFDKNYNL RRFVYCTPFT LDGRAHGDLH
EQFKRKTILT TSHAFPYIKT RINIIHKEEI ISTPIEVAIE DMQKKTQELA FATHQDPADA
KMLQMVLQGS VGTTVNQGPL EVAQVFLSEI PSDPKLYRHH NKLRLYTFKY ALRKNKSLIG
PDQKEYQREL ERNYHRLKEA LQPLINRKIP QLYKPVLQVN SHRDSFSRMS LRKLEI
//
